包装与食品机械2025，Vol.43Issue(2)：50-57,8.DOI:10.3969/j.issn.1005-1295.2025.02.006
红花总黄酮的超声辅助天然低共熔溶剂提取工艺优化
Optimization of ultrasound-assisted natural deep eutectic solvent extraction process of total flavonoids from safflower
摘要
Abstract
To enhance the extraction efficiency of total flavonoids from safflower,this study optimized an ultrasound-assisted extraction process using response surface methodology based on single-factor tests investigating solid-liquid ratio,ultrasonic power,water content in natural deep eutectic solvent(NADES),and molar ratio.The acetylcholinesterase(AChE)inhibitory activity of the extracted flavonoids was further assessed through in vitro assays.Results demonstrated that the optimal conditions included a solid-liquid ratio of 1:25(g/mL),ultrasonic duration of 30 min,temperature of 60 ℃,power of 300 W,NADES water content of 37％,and molar ratio of 1:2.Under these parameters,the total flavonoid extraction efficiency reached 5.07％,with an AChE inhibition rate of 65.52％.This work provides technical insights for advancing safflower flavonoid utilization in functional applications.关键词
红花/总黄酮/天然低共熔溶剂/提取工艺/胆碱酯酶抑制活性Key words
safflower/total flavonoids/natural deep eutectic solvent/extraction process/acetylcholinesterase inhibitory activity分类
轻工业引用本文复制引用
依明·尕哈甫,周朝曦,艾尼娃尔·艾克木,古丽巴哈尔·卡吾力..红花总黄酮的超声辅助天然低共熔溶剂提取工艺优化[J].包装与食品机械,2025,43(2):50-57,8.基金项目
新疆维吾尔自治区自然科学基金项目(2022D01C197) （2022D01C197）
新疆天然药物活性成分与释药技术重点实验室项目(XJDX1713) （XJDX1713）
