食品工业科技2025，Vol.46Issue(9)：363-371,9.DOI:10.13386/j.issn1002-0306.2024050212
复合益生菌改善小鼠抗生素相关性腹泻的作用
Effect of Probiotics Complex on Improving Antibiotic-associated Diarrhea in Mice
陆丽仪 1高业成 2陈君龙 1郭亚娟 1刘华林 1陈昌 1毛新亮3
作者信息
- 1. 完美(广东)日用品有限公司,广东中山 528400
- 2. 内蒙古农业大学,内蒙古呼和浩特 010018||广东完美生命健康科技研究院有限公司,广东中山 528400
- 3. 完美(广东)日用品有限公司,广东中山 528400||广东完美生命健康科技研究院有限公司,广东中山 528400
- 折叠
摘要
Abstract
Probiotics are frequently utilized in clinical practice to mitigate antibiotic-associated diarrhoea(AAD).This study aimed to assess the efficacy of probiotics complex in ameliorating AAD and to elucidate the underlying mechanisms.AAD was induced in mice using a mixture of three antibiotics.The impact of the probiotics complex on fecal properties and colonic tissue structure were evaluated,alongside the expression levels of genes related to intestinal barrier function,short-chain fatty acids,and the structure of the intestinal microbiota community.The results indicated that probiotics complex significantly reduced fecal water content and consistency score in mice(P＜0.05)and significantly increased the levels of acetic acid and butyric acid(P＜0.05).Furthermore,the administration of probiotics complex notably up-regulated the mRNA expression levels of intestinal tight junction proteins ZO-1 and occludin(P＜0.05).Moreover,probiotics complex partially mitigated antibiotic-induced dysbiosis by promoting beneficial bacteria proliferation such as Lachnospiraceae,and reducing conditionally pathogenic species such as Pseudomonas aeruginosa.These results suggest that probiotics complex has the potential to alleviate AAD symptoms,through modulating the gut microbiota and their niche,strengthening the intestinal barrier,and increasing short-chain fatty acid levels.关键词
抗生素相关性腹泻/益生菌/肠道菌群/短链脂肪酸/紧密连接蛋白Key words
antibiotic-associated diarrhea/probiotics/gut microbiota/short-chain fatty acids/tight junction protein分类
轻工纺织引用本文复制引用
陆丽仪,高业成,陈君龙,郭亚娟,刘华林,陈昌,毛新亮..复合益生菌改善小鼠抗生素相关性腹泻的作用[J].食品工业科技,2025,46(9):363-371,9.
