中国食品添加剂2025，Vol.36Issue(5)：59-68,10.DOI:10.19804/j.issn1006-2513.2025.5.008
党参总黄酮的提取及其防脱发作用研究
Extraction of total flavonoids from Codonopsis pilosula and its effects on anti-hair loss effects
摘要
Abstract
A single-factor experimental design was employed to study the extraction of total flavonoids from Codonopsis pilosula(C-Fla).The effect of ultrasonic temperature,ultrasonic time,ethanol concentration,solid-to-liquid ratio and extraction pH on total flavonoid extraction yield was studied.Response surface methodology was used to design the pairwise interaction response surface of three factors with the total flavonoid yield as the optimal index.Following purification with macroporous resin,the anti-hair loss efficacy of the extracted total flavonoids was evaluated.The optimal extraction conditions were found to be as follows:ultrasonic temperature of 48℃,ultrasonic time of 90 minutes,ethanol concentration of 84%,solid-to-liquid ratio of 1∶20 g/mL,and extraction pH of 7.Under these conditions,the flavonoids extracted yield reached 21.680 mg/g.Furthermore,the extracted flavonoids exhibited excellent antioxidant activities,effectively inhibited 5α-reductase activity and promoted cell repair in a DHT-induced alopecia model.These results showed that Codonopsis pilosula flavonoids hold considerable potential in promoting hair growth.The study provides a theoretical basis for further development of Codonopsis pilosula resources.关键词
党参/总黄酮/抗氧化/防脱发作用/5α-还原酶Key words
Codonopsis pilosula/total flavonoids/antioxidant/anti-hair loss/5α-reductase分类
轻工业引用本文复制引用
陈佳慧,季海霞,高莉,郝媛,王鑫涛,张涛涛,郝花花,李建丽..党参总黄酮的提取及其防脱发作用研究[J].中国食品添加剂,2025,36(5):59-68,10.基金项目
山西省重点研发计划项目(202302140601014) （202302140601014）
山西省研究生科研创新项目(2023KY604) （2023KY604）
山西纳安健康科技有限公司横向课题 （）
医药生物技术山西省重点实验室开放课题基金资助(KF202002) （KF202002）
山西省自然科学基金资助(202303021222093) （202303021222093）
山西省高等教育机构科技创新项目资助项目(2023L168) （2023L168）
山西省研究生教育教学改革课题(2022YJJG185) （2022YJJG185）
山西省基础研究计划项目(202203021212115) （202203021212115）
