中国食物与营养2025，Vol.31Issue(4)：21-28,8.
食源性ACE抑制肽的制备方法及作用机制研究进展
Research Progress on Preparation and Mechanism of Action of Food-Derived ACE Inhibitory Peptides
摘要
Abstract
[Objective]To review the mechanism of action of ACE inhibitory peptides in the regulation of hypertension,preparation,isolation and purification,activity evaluation,structure-activity relationship and molecular simulation mechanism of food-derived ACE inhibitory peptides,in order to provide reference for further research and development of ACE inhibitory peptides.[Method]The paper adopted the literature method.[Result]The methods of extracting ACE inhibitory peptides from food materials mainly included enzymatic hydrolysis,fermentation,simulated digestion and synthesis.At present,the separation and purification technology of ACE inhibitory peptides has been relatively mature.Studies on the activity of ACE inhibitory peptides are mainly conducted in vitro and in vivo.Studies on the structure-activity relationship of ACE inhibitory peptides mainly focus on surface hydrophobicity,molecular weight and molecular conformation.Structure-activity relationships have been used to analyze the molecular mechanism of action of ACE-inhibiting peptides.[Conclusion]The studies on the antihypertensive activity and mechanism of food-derived ACE inhibitory peptide in vivo are not systematic and in-depth,and its structure-activity relationship needs to be further studied.The separation and purification process of ACE inhibitory peptides needs to be further improved,and the safety research of foodborne ACE inhibitory peptides and quality management in the produc-tion process need to be strengthened to ensure the safety and health of consumers.关键词
ACE抑制肽/制备方法/活性评价/构效关系/分子机制Key words
ACE inhibitory peptide/preparation method/activity evaluation/constitutive relationship/molecular mechanism引用本文复制引用
王静,王立霞,任彩霞,邓雅之,方丹,冯莉萍..食源性ACE抑制肽的制备方法及作用机制研究进展[J].中国食物与营养,2025,31(4):21-28,8.基金项目
陕西学前师范学院引进人才(博士)科研启动项目(项目编号:2023DS02) （博士）
西安市科技计划项目(项目编号:23NYGG0061) （项目编号:23NYGG0061）
陕西高校青年创新团队"秦岭药食同源生物资源保护与利用创新团队" （）
陕西学前师范学院科研创新团队—陕西特色农产品精深加工技术创新团队"儿童健康照明LED荧光粉". （）
