食品与发酵工业2025，Vol.51Issue(10)：352-359,8.DOI:10.13995/j.cnki.11-1802/ts.040737
Smac的生物学特性及其调控IAPs促进细胞凋亡的研究进展
Research progress in biological characteristics of Smac and its regulating IAPs to promote apoptosis
摘要
Abstract
The second mitochondria-derived activator of caspase(Smac)is a pro-apoptotic protein released from mitochondria,which is located in the mitochondrial membrane gap.Studies have found that the mitochondrial localization signal peptide of Smac is removed,and Smac will be released from mitochondria into the cytoplasm.It can competitively bind to inhibitors of apoptosis proteins(IAPs)or pro-mote the ubiquitination-degradation of IAPs,inhibit the expression of IAPs,and relieve the inhibition of IAPs on caspase,thereby indu-cing the occurrence of apoptosis cascade.This paper summarizes and reviews the biological characteristics of Smac,the ways of Smac regu-lating IAPs to promote apoptosis,and the research progress of Smac regulating IAPs to promote apoptosis of tumor cells,T cells,and mus-cle cells.The future research direction of Smac regulating IAPs to promote apoptosis of tumor cells,T cells and muscle cells is prospected,which can provide new insights for targeted therapy of tumors and the theory of muscle tenderization.关键词
Smac/IAPs/半胱氨酸蛋白酶/细胞凋亡Key words
Smac/IAPs/caspase/apoptosis引用本文复制引用
王敬宇,胡铁英,陈骋,张丽,张玉斌,马国源,李爱霞,师希雄..Smac的生物学特性及其调控IAPs促进细胞凋亡的研究进展[J].食品与发酵工业,2025,51(10):352-359,8.基金项目
国家自然基金项目(32260552) （32260552）
甘肃省自然科学基金项目(24JRRA647) （24JRRA647）
