食品与发酵工业2025，Vol.51Issue(10)：368-375,8.DOI:10.13995/j.cnki.11-1802/ts.040130
生物合成纳米硒对肠道黏膜免疫功能和菌群稳态影响的研究进展
Research progress on effects of biosynthetic selenium nanoparticles on intestinal mucosal immune function and microbial homeostasis
摘要
Abstract
Selenium nanoparticles have been widely used in functional foods and other fields due to their good biocompatibility,bio-availability,and low toxicity.This article reviewed the biosynthesis methods of selenium nanoparticles and research progresses in regulating intestinal mucosal immune function and maintaining intestinal microbiota homeostasis.Selenium nanoparticles could alleviate intestinal in-jury by activating the nuclear factor erythroid 2-related factor 2(Nrf2)pathway and its downstream genes.They exerted anti-inflammatory effects by inhibiting the Toll-like receptor 4(TLR4)/nuclear factor kappa-B(NF-κB)pathway.In the future,researchers could further explore the probiotic mechanism of biosynthesis of selenium nanoparticles,leverage the synergistic effect of probiotics and selenium nanop-articles,and achieve more precise and efficient probiotic effects,based on the foundations provided by this study.关键词
纳米硒/生物合成/肠道屏障功能/菌群稳态/免疫调节Key words
selenium nanoparticles/biosynthesis/intestinal barrier function/microbial homeostasis/immune regulation引用本文复制引用
续丹丹,程怡瑞,黄世猛,刘爽,王凤寰..生物合成纳米硒对肠道黏膜免疫功能和菌群稳态影响的研究进展[J].食品与发酵工业,2025,51(10):368-375,8.基金项目
国家自然科学基金面上项目(22378005) （22378005）
