食品工业科技2025，Vol.46Issue(11)：329-337,9.DOI:10.13386/j.issn1002-0306.2024060055
苦荞来源类外泌体囊泡对C57BL/6小鼠生理影响初探
A Preliminary Study on the Effects of Tartary Buckwheat-derived Nanoparticles on the Physiology of C57BL/6 Mice
摘要
Abstract
Objective:To investigate the effects of dietary supplementation with tartary buckwheat-derived nanoparticles(TBDNs)on key physiological parameters in mice.Methods:Twenty-four C57BL/6 mice were randomly assigned to two groups:a normal control group and a TBDNs group.Changes in body weight,blood biochemical markers,cell histology and immunohistochemistry of the colon and liver,as well as intestinal flora composition,were analyzed.Results:Compared to the normal diet group,the 10 mg TBDNs group exhibited significant reductions in body weight,triglyceride levels,uric acid levels,and alanine aminotransferase activity(P＜0.01).Physiological indicators such as aspartate aminotransferase,cholesterol,high-density lipoprotein,low-density lipoprotein,and creatinine,as well as liver and colon tissues,showed no significant changes(P＞0.05).The abundance of intestinal Lactobacillus,Turicibacter,and Lachnoclostridium species were all significant increased(P＜0.05).Conclusion:Intake of TBDNs has discernible physiological effects on mice,however,further investigations are required to elucidate its underlying mechanisms and potential health benefits.These findings provide novel insights and data for nutritional evaluation of tartary buckwheat.关键词
苦荞/苦荞来源类外泌体囊泡/肠道菌群/营养健康Key words
tartary buckwheat/tartary buckwheat-derived nanoparticles/gut microbiota/nutrition and health分类
轻工纺织引用本文复制引用
张籍月,任朝琴,曹亚楠,任远航,彭镰心..苦荞来源类外泌体囊泡对C57BL/6小鼠生理影响初探[J].食品工业科技,2025,46(11):329-337,9.基金项目
四川省科技厅计划项目(2023ZYD0078) （2023ZYD0078）
现代农业产业技术体系四川杂粮创新团队专项资金(SCCXTD-2024-20) （SCCXTD-2024-20）
阿坝师范学院重点培育项目(AS-PYZD2023-02). （AS-PYZD2023-02）
