食品工业科技2025，Vol.46Issue(11)：359-368,10.DOI:10.13386/j.issn1002-0306.2024110226
植物乳植杆菌CQPC03提升氧化应激损伤小鼠运动能力及肝脏保护作用
Improvement of Exercise Ability and Liver Protection in Oxidative Stress-induced Mice by Lactiplantibacillus plantarum CQPC03
摘要
Abstract
This study investigated the effects of a newly discovered lactic acid bacterium,Lactiplantibacillus plantarum CQPC03(LP-CQPC03),on enhancing the exercise capacity of mice under oxidative stress and elucidated the underlying mechanisms.The oxidative stress model of mice was induced by D-galactose.Through running time,swimming endurance,blood biochemical indexes,histopathological changes,mRNA expression of gastritis muscle and liver tissue,and microbial composition of intestinal contents of mice,LP-CQPC03 was used to explore the improvement of exercise ability and liver protection of mice damaged by oxidative stress.The results showed that after administration of LP-CQPC03(dose 1.5× 109 CFU/kg BW),the running time and swimming endurance of mice with oxidative stress were significantly extended(P＜0.05),and serum lactic acid,blood urea nitrogen(BUN)and creatine kinase(CK)concentrations decreased significantly(P＜0.05),while muscle glycogen(MG)and hepatic glycogen(HG)levels increased significantly(P＜0.05).His-topathological analysis indicated that LP-CQPC03 mitigated oxidative stress damage in the liver tissues of the mice.Further analysis showed that compared with model group,LP-CQPC03 could significantly(P＜0.05)up-regulate expression of adenylate activated protein kinase(AMPK),peroxisome proliferator-activated receptor γ coactivator 1-α(PGC-1α),superoxide dismutase 2(SOD2)and glutathione peroxidase 1(GPx1)mRNA in liver and gastrocnemius muscle of oxidative stress mice.In addition,LP-CQPC03 also increased the abundance of Firmicutes,Lactobacillus and Bifidobacteria in the intestinal tract of mice under oxidative stress,while decreasing the expression of Bacteroidetes.In summary,LP-CQPC03 can not only improve the oxidative stress state of mice,but also significantly enhance their exercise ability,and the effect is better than that of vitamin C(150 mg/kg BW).关键词
植物乳植杆菌/氧化应激/疲劳/运动/肝损伤/肠道菌群Key words
Lactiplantibacillus plantarum/oxidative stress/fatigue/exercise/liver injury/intestinal flora分类
轻工纺织引用本文复制引用
贺波,赵欣,谭晓红,马凯,李采丰..植物乳植杆菌CQPC03提升氧化应激损伤小鼠运动能力及肝脏保护作用[J].食品工业科技,2025,46(11):359-368,10.基金项目
重庆市体育局体育科研项目,体能训练对我市马拉松运动员保障十五运的影响研究(A202460). （A202460）
