食品工业科技2025，Vol.46Issue(11)：379-390,12.DOI:10.13386/j.issn1002-0306.2024060085
重组工程菌发酵生产白藜芦醇研究进展
Research Progress on Resveratrol Production by Recombinant Engineering Bacteria Fermentation
摘要
Abstract
Resveratrol,as a non-flavonoid polyphenol organic compound,has antioxidant,anti-aging,anti-inflammatory,anti-cancer and other functions,and has shown broad application prospects in the food,medicine,and cosmetics industries.Researchers have successfully designed and constructed an efficient heterologous synthesis pathway in microorganisms,and realized the industrial production of resveratrol by large-scale fermentation combined with engineered strains.In this paper,based on the frontier progress in the research of resveratrol biosynthesis,the biosynthetic pathway,the chassis of recombinant engineering bacteria,and the optimization strategy of synthesis methods are reviewed.Two recombinant engineering bacteria,yeast and Escherichia coli,commonly used in the production of resveratrol are introduced and compared.The optimization strategy of resveratrol biosynthesis is proposed from three aspects:The expression of key enzymes,precursors and fermentation processes of resveratrol synthesis.This paper summarizes the existing problems and future development directions,in order to provide theoretical support and reference for the efficient and green biomanufacturing of resveratrol,so as to meet the growing market demand,promote the industrial application of resveratrol in the food industry,and promote the high-quality and sustainable development of the food industry in the future.关键词
白藜芦醇/重组工程菌/生物合成/发酵Key words
resveratrol/recombinant engineered bacteria/biosynthesis/fermentation分类
生物科学引用本文复制引用
谢汶烨,李媛,朱万斌,顾丰颖,焦博,王强..重组工程菌发酵生产白藜芦醇研究进展[J].食品工业科技,2025,46(11):379-390,12.基金项目
新疆油料产业技术体系项目(XJARS-05) （XJARS-05）
国家重点研发计划课题"武都区油橄榄产业提质增效关键技术集成与示范"(2022YFD1602205). （2022YFD1602205）
