中国食物与营养2025，Vol.31Issue(5)：89-95,7.
血清维生素C水平对糖尿病患者死亡风险的影响:一项前瞻性研究
Effect of Serum Vitamin C Levels on Mortality Risk in Diabetic Patients:A Prospective Study
摘要
Abstract
[Objective]To investigate the effect of serum vitamin C levels on all-cause mortality risk in diabetic patients.[Method]Data were collected from NHANES participants aged 20 years and above with diabetes during 2003-2004 and 2005-2006.Cox proportional hazards regression models were used to analyze the association between serum vitamin C levels and all-cause mortality risk,and restricted cubic splines were applied for dose-response analysis.[Result]A total of 484 diabetic patients were included,with a median follow-up of 13.7 years and 211 deaths.Cox analysis revealed that compared to the lowest quartile,moderate levels(third quartile)of serum vitamin C significantly reduced all-cause mortality risk.The restricted cubic spline analysis showed an inverse relationship between serum vitamin C levels and all-cause mortality risk.Risk reduction became significant when levels reached 46-64 μmol/L,while further increases in serum vitamin C levels continued to lower risk,although the change was no longer statistically significant.[Conclusion]Low serum vitamin C levels increase all-cause mortality risk in diabetic patients,whereas moderate levels help reduce this risk.关键词
糖尿病/维生素C/死亡风险Key words
diabetes/vitamin C/mortality risk引用本文复制引用
闵霞,蒋保源,张础涵,郑梦婷,郭连莹..血清维生素C水平对糖尿病患者死亡风险的影响:一项前瞻性研究[J].中国食物与营养,2025,31(5):89-95,7.基金项目
沈阳医学院研究基金(项目编号:20171018). （项目编号:20171018）
