食品科学2025，Vol.46Issue(14)：329-336,8.DOI:10.7506/spkx1002-6630-20250124-184
干制水产品中N-亚硝胺的污染调查和N-二甲基亚硝胺的风险评估
Survey of N-Nitrosamine Contamination and Risk Assessment of N-Nitrosodimethylamine in Dried Aquatic Products
摘要
Abstract
Objective:This study investigated the levels of N-nitrosodimethylamine(NDMA)and eight other N-nitrosamines in dried aquatic products,with a primary focus on assessing the carcinogenic risk of NDMA due to its significant carcinogenicity and dominance among N-nitrosamine contaminants.Methods:Homogenized samples were subjected to steam distillation,and dichloromethane was used to absorb the distillate.Liquid-liquid extraction was employed to purify and separate the target analytes.The concentrated extract was then quantitatively analyzed using ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS).Through three 24-hour dietary recalls,a total of 26 933 volunteers from across the country were surveyed about average daily intake of dried aquatic products.Based on the survey results,the carcinogenic risk of NDMA exposure was assessed by the margin of exposure(MoE)method.Results:The limit of detection(LOD)for NDMA was 0.3 μg/kg.At a spiked level of 2.0 μg/kg,the recoveries of NDMA ranged from 96.9%to 100.1%,with a relative standard deviation(RSD)of 1.56%(n=4).The detection rate of NDMA in commercially available dried aquatic product samples was 77.8%(154/198),at concentrations ranging from 0.51 to 122 μg/kg with an average level of 5.23 μg/kg.Additionally,28.8%of the samples exceeded the maximum allowable limit.The average intake of dried aquatic products among consumers of different age groups ranged from 4.05 to 32.43 g/d,with high consumption(P97.5)ranging from 16.67 to 66.67 g/d.Risk assessment indicated that the dietary exposure to NDMA in people of all age groups with average and high(P97.5)consumption levels of dried aquatic products were 0.46 and 3.65 ng/(kg mb·d),with MoE values of 6.1×104 and 7.7×103,respectively.Conclusion:The potential carcinogenic risk associated with NDMA intake from dried aquatic products is low for all respondents,and the same goes for average consumers across all age groups,who do not require any priority attention.However,NDMA intake poses a potential carcinogenic risk for heavy consumers(P97.5)across all age groups,who require priority attention.关键词
干制水产品/N-二甲基亚硝胺/风险评估/致癌风险Key words
dried aquatic products/N-nitrosodimethylamine/risk assessment/carcinogenic risk分类
轻工业引用本文复制引用
唐翠英,陈华峰,黄棋舒,李建文,黄思婷,陈丽娟,傅武胜..干制水产品中N-亚硝胺的污染调查和N-二甲基亚硝胺的风险评估[J].食品科学,2025,46(14):329-336,8.基金项目
国家食品安全标准制定项目(spaq-2019-041) （spaq-2019-041）
福建省科技创新项目(2019Y2001) （2019Y2001）
