食品与发酵工业2025，Vol.51Issue(12)：29-35,7.DOI:10.13995/j.cnki.11-1802/ts.040284
不同贮存时间白酒摄入对小鼠生物学功能的影响
Effect of Baijiu at different aging time on biological functions of mice
摘要
Abstract
This study established a mouse model by gavage with different aging time Baijiu(0 year,3 years,and 10 years),alco-hol,and water.The biological functions of these Baijiu were evaluated by phenotypic,biochemical,pathological,and behavior analysis.In addition,the immune status of the hippocampus was investigated by using real-time fluorescence quantitative polymerase chain reaction(PCR)combined with Western blot and immunofluorescence analysis.Results showed that chronic excessive intake of both Baijiu and eth-anol caused liver injury in mice.Compared with the fresh Baijiu and ethanol groups,the aged Baijiu group had lower degree of liver inju-ry,a shorter drunkenness time,and a higher sugar preference.In addition,the aged Baijiu can shorten the immobility time under forced swimming stress conditions and increase the exercise distance in the open field test.The aged Baijiu intervention induced a significantly lower degree of inflammatory response in hippocampal tissue than fresh Baijiu and ethanol interventions.This study provides a theoretical basis for the mining of bioactive compounds in aged Baijiu and establishes a technical platform for the exploration of the health value of tra-ditional fermented foods.关键词
老酒/动物模型/肝损伤/行为学/海马体炎症Key words
aged Baijiu/animal model/liver injury/behavior analysis/hippocampal inflammation引用本文复制引用
方程,饶家权,邹永芳,蒲吉洲,徐岩..不同贮存时间白酒摄入对小鼠生物学功能的影响[J].食品与发酵工业,2025,51(12):29-35,7.基金项目
国家自然科学基金项目(22108095) （22108095）
中央高校基本科研业务费专项资金项目(JUSRP123041) （JUSRP123041）
