中国食品添加剂2025，Vol.36Issue(6)：8-12,5.DOI:10.19804/j.issn1006-2513.2025.6.002
显齿蛇葡萄叶水提物增强正常小鼠免疫功能的试验研究
Experimental study on the immuno-enhancement effects of extracts from Ampelopsis grossedentata leaves in normal mice
摘要
Abstract
In order to investigate the effects of aqueous extracts from Ampelopsis grossedentata leaves on the immune function of normal mice,Ampelopsis grossedentata aqueous extract was prepared,and 96 mice were randomly divided into three groups:the first group was used to evaluate the ratio of organ-to-body weight,delayed-type hypersensitivity(DTH)reflection,and half value of hemolysin;the second group was used to detect the phagocytic index using the carbon clearance test;the third group was used to detect NK cell activity.Each major group was further divided into four subgroups:a normal control group,and three treatment groups receiving low,medium and high doses of Ampelopsis grossedentata leaves aqueous extracts(0.5,1.0,2.0 g/kg/day respectively)with 8 mice in each group.The aqueous extract was given by oral administration for 30 days.The results of DTH and NK cell activity tests were both positive.DTH reflection result showed that the mice toes and ankle swelling degrees of medium-and high-dose groups were significantly increased,compared with the control group.NK cell activities in all three dose groups were remarkably elevated,compared with the control group.These findings suggested that aqueous extracts from Ampelopsis grossedentata leaves can effectively enhance the immune function of normal mice.关键词
显齿蛇葡萄/免疫功能/细胞免疫/体液免疫/单核-巨噬细胞功能Key words
Ampelopsis grossedentata/immune function/cellular immunity/humoral immunity/function of mononuclear phagocyte cells分类
轻工业引用本文复制引用
赵晓昂,张东,张方博..显齿蛇葡萄叶水提物增强正常小鼠免疫功能的试验研究[J].中国食品添加剂,2025,36(6):8-12,5.基金项目
中国中医科学院科技创新工程(CI2021B017-17) （CI2021B017-17）
