中国食品添加剂2025，Vol.36Issue(6)：21-30,10.DOI:10.19804/j.issn1006-2513.2025.6.004
植物提取物组合物对紫外线诱导小鼠皮肤色素沉着的改善作用研究
Improving effects of plant extract compositions on ultraviolet light-induced skin pigmentation in mice
摘要
Abstract
This study investigated the effects and mechanisms of plant extract composition(olive fruit powder,osmanthus powder,emblica powder,and water-soluble tomato concentrate)on skin pigmentation in mice.Mice were randomly divided into blank control group,model control group,formula control groups(medium dose BM,high dose BH),and experimental groups(medium dose AM,high dose AH).UV-induced skin pigmentation models were established,and the treatment was administered continuously for 21 days.Subsequently,the skin pigmentation regulatory factors,morphology,histopathological changes,and barrier damage-related indicators were systematically characterized.Additionally,network pharmacology was employed to deeply analyze the key targets and pathways through which the plant extract composition regulates skin pigmentation.The experimental results showed that,compared to the model group,in all dosage groups,tyrosinase(TYR),microphthalmia-associated transcription factor(MITF),advanced glycation end products(AGEs),and malondialdehyde(MDA)were significantly reduced(P＜0.01).Moreover,the AH group exhibited the best improvement in transepidermal water loss(TEWL)and filaggrin(FLG)content.The composition in the AH group regulated key targets such as TP53,TNF,and VEGF through pathways including MAPK,PI3K-Akt,and Ras,thus affecting the biosynthesis and metabolism of melanin.These results suggest that the plant mixture significantly improved ultraviolet-induced pigmentation in mice skin,providing data support for its application in dietary nutritional supplements.关键词
植物提取物组合物/皮肤色素沉着/屏障损伤/网络药理学/膳食补充剂Key words
plant extract composition/skin pigmentation/barrier damage/network pharmacology/dietary supplements分类
轻工业引用本文复制引用
王超跃,陈杰琼,殷光玲,杨晓惠,杜志云,马诗经,苏可文..植物提取物组合物对紫外线诱导小鼠皮肤色素沉着的改善作用研究[J].中国食品添加剂,2025,36(6):21-30,10.基金项目
国家自然科学基金项目(22178070) （22178070）
内蒙古科技新蒙项目(2021CG0029) （2021CG0029）
