食品与机械2025，Vol.41Issue(6)：190-195,6.DOI:10.13652/j.spjx.1003.5788.2024.81003
鹰嘴豆芽素A金属配合物的制备及生物活性探究
Preparation and bioactivity of biochanin A metal complexes
摘要
Abstract
[Objective]To prepare metal complexes of biochanin A(BA)and explore their biological activities.[Methods]Biochanin A was used as the ligand to design and synthesize biochanin A-copper(BA-Cu),biochanin A-zinc(BA-Zn),and biochanin A-chromium(BA-Cr)metal complexes.The structures of the complexes were characterized using methods such as ultraviolet spectroscopy and infrared spectroscopy.The antioxidant activities of the three biochanin A metal complexes were evaluated using the phosphomolybdate complex method,and their anticancer activities were assessed using the CCK-8 assay.[Results]The experiments successfully prepared the three biochanin A metal complexes,i.e.,BA-Cu,BA-Zn,and BA-Cr.All three metal complexes exhibited good antioxidant activities,which were higher than those of the ligand biochanin A and the positive control drug BHT.Among them,BA-Cr exhibited the best antioxidant activity.The three biochanin A metal complexes inhibited the proliferation of human lung cancer A549 cells,cervical cancer Hela cells,and breast cancer MCF-7 cells,with overall inhibitory effects greater than those of the ligand biochanin A.Among them,BA-Zn demonstrated the best anticancer activity.[Conclusion]The three biochanin A metal complexes,BA-Cu,BA-Zn,and BA-Cr,were successfully prepared.Among them,BA-Cr exhibited the best antioxidant activity,while BA-Zn demonstrated the best anticancer activity.关键词
鹰嘴豆/鹰嘴豆芽素A/金属配合物/合成/生物活性Key words
Cicer arietinum L./biochanin A/metal complex/synthesis/bioactivity引用本文复制引用
王有娣,罗盈明,郭俊翔,陈婕,严斌,徐娟娟..鹰嘴豆芽素A金属配合物的制备及生物活性探究[J].食品与机械,2025,41(6):190-195,6.基金项目
国家级大学生创新创业训练计划项目(编号:202213902005) （编号:202213902005）
广东省教育科学规划课题(高等教育专项)(编号:2022GXJK384) （高等教育专项）
广东省本科高校教学质量与教学改革工程建设项目(编号:2022J029) （编号:2022J029）
广东省普通高校创新特色项目(编号:2020KTSCX200) （编号:2020KTSCX200）
