食品与发酵工业2025，Vol.51Issue(14)：236-244,中插2,10.DOI:10.13995/j.cnki.11-1802/ts.039781
益生菌发酵六神曲的制备及其对功能性消化不良小鼠的改善作用
Preparation of Massa Medicata Fermentata fermented by probiotics and its improvement effect on functional dyspepsia mice
摘要
Abstract
The probiotic Massa Medicata Fermentata was prepared through intensive fermentation using Lactiplantibacillus plantarum(CGMCC 29919),Lacticaseibacillus rhamnosus(LH-1),and Lactobacillus acidophilus(LA-1).The effectiveness components were deter-mined and the effects on functional dyspepsia mice were investigated.Results showed that the contents of ferulic acid,rutin,quercitrin,quercetin,and luteolin in the prepared probiotic Massa Medicata Fermentata were increased by 35.98％,191.91％,241.93％,65.25％,and 50.08％respectively.The evaluation of the improvement effect on functional dyspepsia model mice showed that compared with the model group,the gastric emptying rate was increased by 46.26％(P＜0.01),and the small intestinal propulsive rate was increased by 93.50％(P＜0.01),which effectively improved gastrointestinal dynamics and significantly reduced serum IL-4(69.31 pg/mL)and IL-1β(86.81 pg/mL)levels.Furthermore,it could also promote digestion by regulating hormone levels,inhibiting the production of cho-lecystokinin and promoting the release of gastric motility.Meanwhile,it was found that the probiotic Massa Medicata Fermentata improved the structure of the intestinal flora mice,and made the abundance of Lachnospiraceae,Akkermansia,and Lactobacillus increased signifi-cantly,while the abundance of harmful bacteria Ruminococcus and Helicobacter decreased significantly.Results showed that probiotics-en-hanced fermentation of Massa Medicata Fermentata could significantly improve the functional components of Massa Medicata Fermentata,and improve the treatment effect of clinical functional dyspepsia by improving the structure of intestinal flora,regulating the level of gastro-intestinal hormones,enhancing gastrointestinal motility,promoting digestion,and reducing inflammatory reaction.关键词
六神曲/益生菌/成分测定/炎症/功能性消化不良/肠道菌群Key words
Massa Medicata Fermentata/probiotics/composition determination/inflammation/functional dyspepsia/intestinal flora引用本文复制引用
吴金鹏,吴影,曹双双,李璇,张杰,王耀,牛华伟,古绍彬..益生菌发酵六神曲的制备及其对功能性消化不良小鼠的改善作用[J].食品与发酵工业,2025,51(14):236-244,中插2,10.基金项目
河南省重大科技专项项目(231100310200) （231100310200）
河南省重点研发项目(241111314200) （241111314200）
河南省重点研发项目(221111111400) （221111111400）
