CT理论与应用研究2025，Vol.34Issue(4)：589-597,9.DOI:10.15953/j.ctta.2024.274
基于定量CT评估CTD-ILD肺纤维化严重程度的研究
Quantitative CT Assessment of Pulmonary Fibrosis Severity in Patients with Connective Tissue Disease-associated Interstitial Lung Disease
摘要
Abstract
Objective:To classify pulmonary fibrosis severity in connective tissue disease-associated interstitial lung disease(CTD-ILD)patients by integrating visual scoring and quantitative computed tomography(CT).Methods:A total of 96 patients with CTD-ILD and 47 CTD controls without ILD were enrolled.Pulmonary fibrosis was evaluated using the Warrick score and the 3D slicer-based density histogram method.Results:Significant differences were observed in standard deviation(SD),kurtosis,and skewness across the severity groups.Multivariate logistic regression analysis identified HAA as an independent predictor of fibrosis severity.The receiver-operating characterisric curve(ROC)showed that combining all quantitative CT parameters achieved an area under the curve(AUC)of 0.846(sensitivity=0.739 and specificity=0.885)to distinguish normal/mild cases from moderate/severe cases.Weak positive correlations were observed between Perc10,Perc15,MLA,and RV/TLC.Conclusion:This approach enables a noninvasive and objective assessment of CTD-ILD severity,thereby providing a clinically valuable alternative for patients with limitations in pulmonary function testing,reducing diagnostic and therapeutic costs,and demonstrating a strong potential for widespread implementation in primary healthcare settings.关键词
结缔组织病/间质性肺疾病/Warrick评分/定量CT指标/肺间质纤维化严重程度Key words
connective tissue disease(CTD)/interstitial lung disease(ILD)/Warrick score/quantitative CT metrics/severity of pulmonary fibrosis分类
医药卫生引用本文复制引用
王珂,胡子涛,崔露露,郭声雅,黄晓旗..基于定量CT评估CTD-ILD肺纤维化严重程度的研究[J].CT理论与应用研究,2025,34(4):589-597,9.基金项目
陕西省科技厅重点研发计划(基于体素对吸烟者肺结构损伤的定量研究(2021SF-254)) （基于体素对吸烟者肺结构损伤的定量研究(2021SF-254）
延安大学教育创新项目(基于定量CT评估类风湿关节炎相关间质性肺疾病(YCX2024116)). （基于定量CT评估类风湿关节炎相关间质性肺疾病(YCX2024116）
