CT理论与应用研究2025，Vol.34Issue(4)：604-610,7.DOI:10.15953/j.ctta.2025.081
AAV-ILD的CT影像学特征与ANCA浓度的相关性分析研究
Computer Tomography Features of Antineutrophil Cytoplasm Antibody-associated Vasculitis-interstitial Lung Disease and Its Correlation with Antineutrophil Cytoplasmic Antibody Concentration
摘要
Abstract
This study systematically analyzed the CT imaging features of patients diagnosed with ANCA-associated vasculitis(AAV)-related interstitial lung disease(ILD)at the time of their first diagnosis.The types and distribution characteristics of the lesions and their correlation with laboratory findings were investigated.A retrospective study was conducted on 92 patients with newly diagnosed AAV-ILD.Clinical and CT imaging data were collected.CT imaging data were analyzed qualitatively and quantitatively to evaluate lesion types(e.g.,ground-glass opacities,reticulations,honeycombing,consolidation,and traction bronchiectasis)and their distribution patterns.The severity of the lesions was quantified using a pulmonary fibrosis scoring system,and the correlation between imaging features and laboratory indices was analyzed.AAV-ILD was more commonly observed in elderly male patients.Honeycombing and reticulations were the most common CT-imaging findings,with lesions primarily distributed in the bilateral lower lungs and peripheral regions.AAV-ILD predominantly exhibited a usual interstitial pneumonia(UIP)pattern.A significant positive correlation was also observed between the pulmonary fibrosis score and myeloperoxidase(MPO)concentration and between honeycombing scores and MPO concentration.The CT features of AAV-ILD are unique.The correlation between MPO and pulmonary fibrosis suggests that MPO may serve as a potential biomarker for the progression of pulmonary fibrosis.These findings provide important insights into the imaging characteristics and pathological mechanisms of AAV-ILD.关键词
抗中性粒细胞胞浆抗体/间质性肺病/高分辨率CT/磨玻璃影/蜂窝样改变Key words
antineutrophil cytoplasmic antibodies/interstitial lung disease/high-resolution CT/ground-glass opacities/honeycomb lung分类
医药卫生引用本文复制引用
王红梅,李俊林,董宇清,张月阳,姚韧寰..AAV-ILD的CT影像学特征与ANCA浓度的相关性分析研究[J].CT理论与应用研究,2025,34(4):604-610,7.基金项目
内蒙古医学科学院公立医院科研联合基金科技项目(2024GLLH0033 （）
2023GLLH0030). （）
