中国食品添加剂2025，Vol.36Issue(7)：11-19,9.DOI:10.19804/j.issn1006-2513.2025.7.002
磷虾油鱼油软胶囊稳定性及辅助降血脂作用的人体试食研究
Stability and adjunct lipid-lowering effect of krill oil and fish oil soft capsules in a human dietary intervention study
杨彩玲 1杨溢 2田燕 1程刚 3李帅 3田世民4
作者信息
- 1. 中检科(北京)测试技术有限公司,北京 100176
- 2. 康奥科技集团有限公司,天津 300011
- 3. 北京康立生医药技术开发有限公司,北京 100176
- 4. 中检科(北京)测试技术有限公司,北京 100176||中国检验检疫科学研究院,北京 100176
- 折叠
摘要
Abstract
In order to investigate the stability of eicosapentaenoic acid(EPA)and docosahexaenoic acid(DHA)in a combined krill oil and fish oil soft capsule,and to evaluate its hypolipidemic effect and safety in individuals with hyperlipidemia;Accelerated degradation testing was conducted to determine EPA and DHA content in the soft gels capsule stored for 0,1,2,and 3 months.Subsequently,a randomized,placebo-controlled trial was performed.One hundred three subjects(N=103)with hyperlipidemia were randomly assigned to receive either krill oil and fish oil soft capsule(Test Group)or a placebo of equivalent dosage(Control Group)daily for 90 days.Changes in serum lipid profiles TC,TG,LDL,HDL and any reported symptoms were assessed.The results showed that the EPA and DHA content in the krill oil and fish oil soft capsule remained stable under accelerated conditions,showing no significant degradation over the 3-month test period.In the human trial,the test group experienced significant reductions in serum TC,TG,and LDL-C levels compared to the control group.Serum HDL-C levels did not change significantly in either group.Participants receiving the krill oil and fish oil soft capsule also reported improvement in primary clinical symptoms.No adverse reactions or allergic symptoms were observed during the study period.Therefore,the EPA and DHA in the krill oil and fish oil soft capsule were stable and controllable,serving as quality control indicators for efficacy studies.This product demonstrated significant lipid-lowering effect and had no side effects in humans.关键词
磷虾油/鱼油/稳定性/调脂功能/人体试食试验Key words
krill oil/fish oil/stability/lipid regulation/human dietary intervention分类
轻工纺织引用本文复制引用
杨彩玲,杨溢,田燕,程刚,李帅,田世民..磷虾油鱼油软胶囊稳定性及辅助降血脂作用的人体试食研究[J].中国食品添加剂,2025,36(7):11-19,9.
