中国食品添加剂2025，Vol.36Issue(7)：61-66,6.DOI:10.19804/j.issn1006-2513.2025.7.008
母乳植物乳植杆菌R9的益生特性和安全性研究
Probiotic characteristics and safety evaluation of Lactiplantibacillus plantarum R9 isolated from human breast milk
摘要
Abstract
Human breast milk was recognized not only as a natural source of nutrition for infant growth and development,but also as an important reservoir for screening microorganisms with potential probiotic properties.This study evaluated the probiotic properties and safety of a strain of Lactiplantibacillus plantarum R9 isolated from healthy human breast milk.Its growth curve and its tolerance in different acidic and bile-salt environments were evaluated,and its safety was assessed in terms of bacteriostatic functional properties and antibiotic resistance.The results showed that L.plantarum R9 had good growth characteristics,strong acid(pH 2.5)and bile salt(0.3％)tolerance.R9 had a certain inhibitory effect on eight common pathogens,especially on Escherichia coli and Salmonella typhi,which had the strongest inhibitory effect.Among the 10 antibiotics,R9 was extremely sensitive to erythromycin,azithromycin,ampicillin,amikacin,clindamycin,ceftriaxone and ciprofloxacin,and moderately sensitive to chloramphenicol,and resistant to penicillin G and tetracycline.Lactiplantibacillus plantarum R9 was demonstrated to possess favorable probiotic properties and safety.关键词
植物乳植杆菌/耐酸性/耐胆盐/抑菌/耐药性Key words
Lactiplantibacillus plantarum/acid tolerance/bile salt tolerance/antibacterial activity/antibiotic resistant分类
轻工纺织引用本文复制引用
尹春媚,吴泽熠,刚永运..母乳植物乳植杆菌R9的益生特性和安全性研究[J].中国食品添加剂,2025,36(7):61-66,6.基金项目
北京市科技计划课题(Z221100006422012) （Z221100006422012）
