食品与发酵工业2025，Vol.51Issue(15)：59-65,7.DOI:10.13995/j.cnki.11-1802/ts.041221
林蛙卵油对高脂血症大鼠血脂调控的活性研究
Regulatory activity of Rana chensinensis ovum oil on blood lipid of hyperlipidemic rats
摘要
Abstract
To further elucidate the lipid-lowering effect of Rana chensinensis ovum oil,rat model of hyperlipidemia was constructed firstly,with simvastatin as a control to compare the effect on serum lipid level,antioxidant factor level,inflammatory factor level,liver function indicator of test rats in different doses of R.chensinensis ovum oil intragastric administration.Calculated the body weight and major organ index of test rats,and observed the pathological changes of liver tissue.Results showed that during the construction of the hyperlipi-demia model,there was a significant increase in rat body weight(P＜0.05),while intervention by R.chensinensis ovum oil resulted in a significant decrease(P＜0.05).R.chensinensis ovum oil significantly reduced the level of serum insulin,total cholesterol,triglyceride,low density lipoprotein cholesterol,IL-6,IL-1β,TNF-α,aspartate aminotransferase,alanine aminotransferase,and malondialdehyde of hyperlipidemic rats(P＜0.05),and increased the level of high density lipoprotein cholesterol,superoxide dismutase,and glutathione peroxidase(P＜0.05).The liver and kidney index of hyperlipidemic rats increased significantly(P＜0.05),and significantly decreased after intervention by R.chensinensis ovum oil(P＜0.05).The liver tissue structure of hyperlipidemic rats was severely abnormal,and showed diffuse steatosis.After intervention by R.chensinensis ovum oil,the liver tissue structure gradually returned.The study indicated that R.chensinensis ovum oil has well blood lipid regulation activity on hyperlipidemic rats,which will provide new ideas for the treatment of hyperlipidemia.关键词
林蛙卵油/高脂血症/大鼠模型/降血脂/调控活性Key words
Rana chensinensis ovum oil/hyperlipidemia/rat model/hypolipidemic/regulatory activity引用本文复制引用
赵文萱,鞠志刚..林蛙卵油对高脂血症大鼠血脂调控的活性研究[J].食品与发酵工业,2025,51(15):59-65,7.基金项目
国家重点研发计划项目(2020YFC2006002-03) （2020YFC2006002-03）
