食品与机械2025，Vol.41Issue(8)：1-9,9.DOI:10.13652/j.spjx.1003.5788.2025.80422
具有拮抗幽门螺杆菌能力的乳酸菌筛选及分析
Screening and analysis of lactic acid bacteria with anti-Helicobacter pylori activity
魏子程 1范柳萍 1李进伟1
作者信息
- 1. 江南大学食品学院,江苏 无锡 214000
- 折叠
摘要
Abstract
[Objective]To identify and screen lactic acid bacteria(LAB)strains with antagonistic activity against Helicobacter pylori,addressing the increasing antibiotic resistance and declining H.pylori eradication rates.[Methods]LAB strains with anti-H.pylori activity were screened in vitro.The safety and probiotic properties of the selected strain were investigated,and its efficacy in alleviating H.pylori infection was validated via anti-inflammatory assays using gastric adenocarcinoma cell lines.[Results]The selected strain exhibited a clear inhibition zone against H.pylori with a diameter of 15.44 mm and a co-aggregation rate of 32.84%.Genomic annotation and antimicrobial susceptibility testing indicated a high safety profile.Cell inflammation assays demonstrated that the strain could reduce IL-8 secretion induced by the model by up to 78.18%.[Conclusion]The selected LAB strain effectively inhibits H.pylori growth and alleviates gastric inflammation,combining multiple probiotic characteristics with low pathogenic risk,providing a new probiotic candidate for combating H.pylori-associated gastrointestinal diseases.关键词
乳酸菌/幽门螺杆菌/抗菌活性/共聚集/基因注释Key words
lactic acid bacteria/Helicobacter pylori/antimicrobial activity/co-aggregation/genomic annotation引用本文复制引用
魏子程,范柳萍,李进伟..具有拮抗幽门螺杆菌能力的乳酸菌筛选及分析[J].食品与机械,2025,41(8):1-9,9.
