食品与机械2025，Vol.41Issue(8)：143-148,6.DOI:10.13652/j.spjx.1003.5788.2025.80395
原花青素B2抗氧化与抗炎活性及分子机制研究
Antioxidant and anti-inflammatory activities and molecular mechanisms of procyanidin B2
摘要
Abstract
[Objective]To explore the mechanism by which procyanidin B2(PB2)intervenes in inflammation and insulin resistance(IR)through multi-target modulation.[Methods]The potential of PB2 in diabetes prevention was evaluated via in vitro antioxidant assays,and molecular biology techniques were used to reveal the regulatory effect of PB2 on the NF-κB inflammatory signaling pathway during the progression of IR.[Results]PB2 significantly reduced reactive oxygen species(ROS)levels in HepG2 cells by scavenging free radicals and inhibited the expression of inflammatory factors IL-6,IL-1β,and TNF-α.By suppressing the JNK/NF-κB signaling cascade,PB2 blocked excessive ROS production,thereby restoring intracellular redox homeostasis and ultimately improving insulin resistance.[Conclusion]PB2 can regulate glucose metabolism and antagonize inflammatory responses by modulating redox balance and inflammatory signaling pathways.关键词
原花青素B2/抗氧化/抗炎/JNK/NF-κB/胰岛素抵抗Key words
procyanidin B2/antioxidant/anti-inflammatory/JNK/NF-κB/insulin resistance引用本文复制引用
杨文丽,覃思,吕承豪,王旖雪,陈诗韵..原花青素B2抗氧化与抗炎活性及分子机制研究[J].食品与机械,2025,41(8):143-148,6.基金项目
国家重点研发计划(编号:2019YFC1604903,2022YFC2010100) （编号:2019YFC1604903,2022YFC2010100）
湖南省自然科学基金(编号:2023JJ30295) （编号:2023JJ30295）
