食品与发酵工业2025，Vol.51Issue(17)：118-127,10.DOI:10.13995/j.cnki.11-1802/ts.041111
低黏魔芋葡甘聚糖对急性酒精中毒小鼠的保护作用
Alcohololytic effect of low-viscosity konjac glucomannan in mice with acute alcohol intoxication
摘要
Abstract
To investigate the protective effects of low-viscosity konjac glucomannan(LVKGM)on acute alcohol intoxication in mice,konjac glucomannan(KGM)powder was used as the raw material.LVKGM was prepared using microwave-assisted hydrogen peroxide(semi-dry method).C57BL mice served as the animal model,with KGM as the positive control.Behavioral observations,biochemical as-sessments,and pathological examinations were conducted to evaluate effects of LVKGM on alcohol metabolism and intoxication protection in acute alcohol intoxicated mice,revealing potential mechanisms of action.The results indicated that LVKGM reduced serum levels of as-partate aminotransferase(AST)and alanine aminotransferase(ALT)in acute alcohol intoxicated mice.LVKGM downregulated the expres-sion of inflammatory factors such as TNF-α in the liver,alleviating the inflammatory response.Additionally,LVKGM enhanced the activity of alcohol dehydrogenase(ADH)in the liver,accelerating alcohol metabolism.It also increased the activities of glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD),thereby strengthening antioxidant defense of the liver.Furthermore,LVKGM raised the concentration of short-chain fatty acids(SCFAs)in the colonic contents of alcohol-intoxicated mice and improved cecal microbiota diversi-ty,effectively mitigating the damage caused by acute alcohol intoxication.In conclusion,LVKGM prepared by the microwave-assisted hy-drogen peroxide method demonstrated significant protective effects against acute alcohol damage in mice.The findings suggested that these effects may be related to the improvement of gut-liver axis function,restoration of gut barrier integrity,and modulation of gut microbiota and inflammatory responses.This research provides new experimental evidence for the potential use of LVKGM as a therapeutic food for acute alcohol poisoning and daily liver and gastric protection during alcohol consumption.关键词
魔芋葡甘聚糖/低黏/急性酒精中毒/解酒护肝Key words
konjac glucomannan/low viscosity/acute alcohol intoxication/detoxification and liver protection引用本文复制引用
陈鸿,刘丁与,杜宇明,钟耕..低黏魔芋葡甘聚糖对急性酒精中毒小鼠的保护作用[J].食品与发酵工业,2025,51(17):118-127,10.基金项目
四川省科技成果转移转化示范项目(2023ZHCG0080) （2023ZHCG0080）
