中国食物与营养2025，Vol.31Issue(8)：62-68,7.
非靶向代谢组学分析低聚果糖联合茶多酚预防高蔗糖膳食诱导的代谢异常现象
Non-Targeted Metabolomics Analysis of Fructooligosaccharides Combined with Tea Polyphenols to Prevent Metabolic Abnormalities Induced by High Sucrose Diet
摘要
Abstract
[Objective]To reveal the mechanism of fructo-oligosaccharide(FOS)combined with tea polyphenols in preventing metabolic abnormalities induced by high sucrose diet.[Method]Commercial kits and liver pathological tissue sections were used to reveal lipid metabolism.The changes of serum metabolic fingerprints in mice that fed with 30%fructose for continuous 8 weeks were researched by metabonomics technology based on ultra-performance liquid chromatography-flight time mass spectrometry.[Result]There were 12 dif-ferential metabolites.They participated in sphingolipid,fatty acid biosynthesis and degradation,glycerolipid,glycerophpspholipid and arachidonic acid metabolisms.In addition,the preventive effects of fructo-oligosaccharide(FOS)and tea polyphenols on the metabolic disturbance induced by high sucrose diet were also researched.[Conclusion]Intake of FOS combined with tea polyphenols was effectively than FOS or tea polyphenols ingestion separately to prevent sucrose induced-metabolic disturbance.关键词
蔗糖/低聚果糖/茶多酚/代谢紊乱/代谢组学Key words
sucrose/fructo-oligosaccharide/tea polyphenols/metabolic dysfunction/metabonomics引用本文复制引用
张堃,李文峰,魏良洲..非靶向代谢组学分析低聚果糖联合茶多酚预防高蔗糖膳食诱导的代谢异常现象[J].中国食物与营养,2025,31(8):62-68,7.基金项目
重庆市自然科学基金项目(项目编号:cstc2019jcyj-msxmX0141). （项目编号:cstc2019jcyj-msxmX0141）
