中国食品添加剂2025，Vol.36Issue(10)：51-61,11.DOI:10.19804/j.issn1006-2513.2025.10.007
山药多糖-纳米硒复合物在模拟胃肠液中的释放动力学及机制
Release kinetics and mechanisms of yam polysaccharide-nano selenium complexes in simulated gastrointestinal fluids
摘要
Abstract
The release behavior of selenium from the yam polysaccharide-nanoselemium complex in simulated gastrointestinal fluids was investigated to understand its release profile and mechanisms in the body.Particle size distribution of yam polysaccharide-nanoselenium complex before and after simulated gastrointestinal digestion was measured by nanoparticle size analyzer,and the morphology of yam polysaccharide-nanoselenium complex particles before and after simulated gastrointestinal digestion was observed by atomic force microscopy(AFM).After in vitro digestion,fitting analyses of selenium were performed using five kinetic models:zero order,first order,Higuchi,Hixson-Crowell,and Korsmeyer-Peppas model.After simulated gastrointestinal digestion,the size of the yam polysaccharide-nanoselenium complex increased significantly,and the boundary was gradually blurred.The release of Se from three yam polysaccharide-nanoselenium complexes with different selenium/polysaccharide ratios(selenium/polysaccharide=1∶3,1∶1,4∶3)in simulated gastrointestinal fluid showed a classical Fickian diffusion release mechanism.The selenium/polysaccharide ratio of 1∶1 yam polysaccharide-nanoselenium complex had a lower Se release in the simulated gastric fluid and a higher Se release in the simulated intestinal fluid.Therefore,the yam polysaccharide-nanoselemium complex was suggested to be an effective in vitro selenium delivery carrier,with potential applications in the food and pharmaceutical industries.关键词
山药多糖-纳米硒复合物/体外消化/动力学模型/释放机制Key words
yam polysaccharide-nanoselenium/in vitro digestion/dynamic model/release mechanism分类
轻工纺织引用本文复制引用
肖益东,钟瑞,孙雨悦..山药多糖-纳米硒复合物在模拟胃肠液中的释放动力学及机制[J].中国食品添加剂,2025,36(10):51-61,11.基金项目
武汉市知识创新专项曙光计划项目(2023020201020476) （2023020201020476）
