轻工学报2025，Vol.40Issue(5)：37-43,54,8.DOI:10.12187/2025.05.005
噬菌体及其衍生物抗食源性致病菌生物被膜的研究进展
Research progress of bacteriophages and their derivatives against foodborne pathogens biofilms
摘要
Abstract
Biofilm(BF)is the predominant form of foodborne pathogenic bacteria during food processing.It has a complex structure,making it difficult for conventional disinfection and sterilization methods to eradicate it.Prevention and control strategies for biofilms are gradually becoming a research focus in the food field.Based on the severe situation in the prevention and control of foodborne pathogenic bacteria and the potential of bacteriophages as biological control agents,this review summarizes the formation process and main regulatory mechanisms of biofilms,as well as the research progress on bacteriophages and their derivatives,and the combination of bacteriophages and antibiotics in targeting biofilms of foodborne pathogenic bacteria.The formation process of biofilm generally includes the reversible adhesion stage,irreversible adhesion stage,early formation stage,maturation stage,and dispersion stage.Quorum sensing is the main factor that regulates biofilm formation.Bacteriophages can specifically target foodborne pathogenic bacteria.Their derivatives,lysin and holin,can degrade the peptidoglycan of bacteria,leading to bacterial cell lysis and the release of progeny bacteriophages.The combination of bacteriophages and antibiotics can produce a synergistic effect and improve the effect of prevention and control of biofilms formed by foodborne pathogenic bacteria.Future research will integrate the One Health concept,investigate the cross-transmission mechanism of biofilms in the"human-animal-environment"system from the fields of medicine,food,and environment,optimize the combination conditions of bacteriophages and antibiotics,and enhance the effect of multi-strategy synergistic prevention and control to better ensure food quality and safety.关键词
食源性致病菌/生物被膜/噬菌体/生物防治剂/抗生素Key words
foodborne pathogenic bacteria/biofilm/phage/biological control agent/antibiotic分类
轻工纺织引用本文复制引用
孙新城,杜月霞,周军,杜婷婷,秦金梦,张思威,张晓根..噬菌体及其衍生物抗食源性致病菌生物被膜的研究进展[J].轻工学报,2025,40(5):37-43,54,8.基金项目
河南省科技攻关项目(242102111045,222102520041,222103810020) （242102111045,222102520041,222103810020）
