沈阳农业大学学报2025，Vol.56Issue(5)：52-61,10.DOI:10.3969/j.issn.1000-1700.2025.05.006
术后辅助化疗对犬管状乳头癌的治疗效果研究
Study on the Therapeutic Effect of Postoperative Adjuvant Treatment on Canine Ductal Papillary Cancer
摘要
Abstract
[Objective]This study aimed to identify the method that maximally prolongs the postoperative survival period in dogs with mammary tumors.[Methods]We first collected 112 cases of canine mammary tumors(CMTs)from the Shenyang region and conducted a detailed epidemiological investigation,including age,etiology,and histopathological examination.The most common and highest incidence malignancy,tubulopapillary carcinoma(grades Ⅰ,Ⅱ,and Ⅲ),was selected for targeted treatment.The average survival times of dogs undergoing surgery alone were compared with those receiving surgery combined with postoperative adjuvant chemotherapy.[Results]The results showed that among the 112 CMT cases,40 were benign(35.71%),primarily complex adenomas,and 72 were malignant(64.29%),predominantly tubulopapillary carcinomas.The peak age of onset was 10-12 years,with the inguinal nipples being the most common sites.In the treatment trial,For Grade Ⅰ tubulopapillary carcinoma,the average survival time in the adjuvant chemotherapy group was lower than that in the surgery-alone group,while the difference in average survival time between the two treatment regimens was not significant(P>0.05).For Grade Ⅱ and Ⅲ tubulopapillary carcinomas,the average survival time in the adjuvant chemotherapy group was significantly higher than that in the surgery-alone group,and the difference in average survival time between treatment regimens was significant for Grade Ⅱ(P<0.05)and extremly significant for Grade Ⅲ(P<0.01).These results indicate that surgery alone is more suitable for Grade Ⅰ tubulopapillary carcinoma,while postoperative adjuvant chemotherapy combined with surgery is more suitable for GradeⅡandⅢtubulopapillary carcinomas.This study provides a foundation for guiding the clinical treatment of canine tubulopapillary carcinoma.[Conclusion]These results indicate that surgery alone is more suitable for GradeⅠ tubulopapillary carcinoma,while postoperative adjuvant chemotherapy combined with surgery is more suitable for Grade Ⅱ and Ⅲtubulopapillary carcinomas.This study provides a foundation for guiding the clinical treatment of canine tubulopapillary carcinoma.关键词
犬/乳腺肿瘤/管状乳头癌/术后辅助化疗/中位存活时间Key words
dog/mammary tumors/tubulopapillary carcinoma/postoperative adjuvant chemotherapy/median survival time分类
农业科技引用本文复制引用
孙雨航,李卓儒,朱思雨,杨淑华..术后辅助化疗对犬管状乳头癌的治疗效果研究[J].沈阳农业大学学报,2025,56(5):52-61,10.基金项目
新瑞鹏青年教师基本科研项目(RPJJ2021026) （RPJJ2021026）
沈阳农业大学人才引进专项——博士启动基金项目(880420005) （880420005）
