食品工业科技2025，Vol.46Issue(23)：31-38,8.DOI:10.13386/j.issn1002-0306.2025020184
载虾青素的亚麻籽副产物蛋白/果胶乳液对非酒精性脂肪肝的干预作用
Intervention of Astaxanthin-ioaded Flaxseed By-product Protein/Pectin Emulsion in Non-alcoholic Fatty Liver Disease
郝薛宇 1孙晓玲 1于洪梅 1杜金1
作者信息
- 1. 长春职业技术大学,吉林长春 130033
- 折叠
摘要
Abstract
To enhance the economic value of flaxseed processing by-products while addressing the challenges of astaxanthin's poor water solubility,low stability,and limited bioavailability,this study developed composite emulsifiers(FP/PCs)via electrostatic interactions between flaxseed meal protein(FP)and pectin(PC)to stabilize astaxanthin-loaded emulsions.The potential therapeutic application of these emulsions in non-alcoholic fatty liver disease(NAFLD)was further investigated.The optimal pH for FP/PC complex formation was determined to be 3.5 based on Zeta potential measurements.Wettability analysis revealed that FP/PC-1.00％exhibited the highest three-phase contact angle(74.2°).In vitro simulated digestion and antioxidant assays were conducted to evaluate the emulsion's protective effects on astaxanthin and its functional bioactivity.Notably,F-1.00％-AXT retained 66.98％of astaxanthin after digestion,with the resulting emulsion micelles(FM-AXT)displaying a particle size of 507 nm-suitable for cellular uptake.In an oleic acid-induced NAFLD cell model,FX-AXT outperformed free astaxanthin by significantly reducing intracellular ROS levels(P＜0.01),demonstrating enhanced antioxidant capacity.Furthermore,Oil Red O staining and quantitative lipid analysis(TG,T-CHO)confirmed FX-AXT's potent lipid-lowering effects.This study successfully engineered a flaxseed by-product-derived protein/pectin composite emulsion that improved astaxanthin delivery and bioactivity.The findings present a promising functional food-based strategy for NAFLD management while adding value to flaxseed processing waste.关键词
亚麻籽加工副产物/亚麻籽粕蛋白/果胶/虾青素乳液/非酒精性脂肪肝细胞模型Key words
flaxseed processing by-products/flaxseed meal protein/pectin/astaxanthin emulsion/cellular model of non-alcoholic fatty liver分类
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郝薛宇,孙晓玲,于洪梅,杜金..载虾青素的亚麻籽副产物蛋白/果胶乳液对非酒精性脂肪肝的干预作用[J].食品工业科技,2025,46(23):31-38,8.
