食品工业科技2025，Vol.46Issue(23)：212-220,9.DOI:10.13386/j.issn1002-0306.2024110307
凝结魏茨曼氏菌CGMCC 9951对酒精性肝损伤小鼠肠道菌群的调节作用
Regulatory Effect of Weizmannia coagulans CGMCC 9951 on Intestinal Flora in Mice with Alcoholic Liver Disease
摘要
Abstract
Objective:The mitigative effect of Weizmannia coagulans CGMCC 9951 on alcohol-induced liver injury and its regulatory effect on intestinal microbiota were investigated.Methods:An alcohol-induced liver injury mouse model was established,and Weizmannia coagulans CGMCC 9951 was intervened at low,medium,and high doses for 4 weeks.Behavioral,physiological,biochemical,and antioxidant indicators were measured,and the changes in the intestinal microbiota were analyzed.Results:Weizmannia coagulans CGMCC 9951 significantly prolonged the drunk incubation period,alleviated alcohol-induced organ index abnormalities,lowered serum ALT and AST levels,and improved the antioxidant capacity of the liver in mice(P＜0.05).The analysis of microbial diversity showed significant differences in the microbial structure among groups.At the phylum level,intervention of Weizmannia coagulans CGMCC 9951 increased the abundance of Firmicutes and decreased the abundance of Verrucomicrobiota.At the genus level,the abundance of beneficial genera Lactobacillus and Eubacteria increased,while the abundance of pathogenic genus Enterobacter decreased.Functional prediction showed that Weizmannia coagulans CGMCC 9951 might play a role through tryptophan metabolism and butanoate metabolism pathways.Conclusion:Weizmannia coagulans CGMCC 9951 may improve alcoholic liver injury by enhancing antioxidant capacity,increasing the abundance of beneficial bacteria in the gut,reducing the abundance of pathogenic bacteria,and maintaining the stability of the gut microbiota.关键词
凝结魏茨曼氏菌/酒精性肝损伤/肠道菌群/益生菌Key words
Weizmannia coagulans/alcoholic liver disease/intestinal flora/probiotics分类
轻工业引用本文复制引用
李成,吴影,郭明涵,段梦瑶,张杰,古绍彬..凝结魏茨曼氏菌CGMCC 9951对酒精性肝损伤小鼠肠道菌群的调节作用[J].食品工业科技,2025,46(23):212-220,9.基金项目
国家自然基金青年基金项目(32302069) （32302069）
河南省青年托举人才项目(20230035). （20230035）
