食品与机械2025，Vol.41Issue(10)：59-66,8.DOI:10.13652/j.spjx.1003.5788.2024.80100
大型鼓泡式生物反应器气液两相流的数值模拟及优化
Numerical simulation and optimization of gas-liquid two-phase flow in a large-scale bubble column bioreactor
摘要
Abstract
[Objective]To conduct flow field simulation analysis on an 80-ton bubble column bioreactor for equipment improvement and fermentation efficiency enhancement.[Methods]Computational fluid dynamics is resorted to numerical simulation of gas-liquid two-phase flow in a bubble column bioreactor.Euler-Euler method and k-ε model are used to simulate the turbulence of gas-liquid two-phase flow.The population balance model(PBM)is coupled to predict bubble size.The flow pattern,liquid velocity,energy dissipation rate,gas holdup,and bubble size distribution inside the reactor are simulated.Based on the permeation model,the calculation is performed on the volumetric oxygen transfer coefficient(kLa)inside the reactor,and an analysis is conducted on the influence of different reflux angles and diameters of the reflux pipe on the reactor's oxygen supply capacity.[Results]The reflux pipe significantly impacts the reactor's flow field,and positively impacts the liquid velocity,energy dissipation rate,and bubble size.The volumetric oxygen transfer coefficient of the reactor reaches 1 093 h-1.There is an interactive effect between the reflux angle and the diameter of the reflux pipe,with the optimal combination as a diameter of 150 mm and an angle of 45°.Under these conditions,the volumetric oxygen transfer coefficient reaches 1 428 h-1.[Conclusion]The reflux pipe makes the bubble column reactor comparable to the stirred reactor of the same scale in terms of oxygen supply capacity,playing a crucial role.关键词
计算流体力学/欧拉—欧拉模型/体积氧传质系数/鼓泡反应器/回流管Key words
computational fluid dynamic/Euler-Euler model/volumetric oxygen transfer coefficient/bubble column reactor/reflux pipe引用本文复制引用
王龙,孙雅芳,覃先武,张彦,李超..大型鼓泡式生物反应器气液两相流的数值模拟及优化[J].食品与机械,2025,41(10):59-66,8.基金项目
湖北省自然科学基金创新发展联合基金项目(编号:2025AFD284) （编号:2025AFD284）
