中国食物与营养2025，Vol.31Issue(11)：57-63,7.
海洋鱼皮低聚肽对自然衰老小鼠皮肤改善的作用研究
Effect of Marine Fish Skin Oligopeptides on Skin Improvement in Natural Aging Mice
摘要
Abstract
[Objective]To observe the effect of marine fish skin oligopeptides on skin improvement in 30-month-old natural aging mice.[Method]30-month-old male C57BL/6 mice(n=11)were randomly divided into old control group(n=5)and old experimental group(n=6).And 14-week-old male C57BL/6 mice(n=18)were randomly divided into young control group(n=9)and young experimental group(n=9).Mice in the experimental group drank 25 mg/mL marine fish skin oligopeptides solution,and mice in the control group drank deionized water.The intervention lasted for 7 weeks.The observed indexes included SOD activity,MDA content,water content,Hydroxyproline content in skin tissues of mice.Spleen,thymus and liver were collected to calculate the viscera index.[Result]SOD activity in skin tissue of old experimental group was significantly higher than that of old control group(P<0.01),while MDA content in skin tissue of young experimental group was significantly lower than that of young control group(P<0.05).The spleen index of mice in the old control group was significantly higher than that in the young control group(P<0.05),and the spleen index of mice in the old experimental group was significantly lower than that in the old control group(P<0.05).[Conclusion]Appropri-ate supplementation of marine fish skin oligopeptides can effectively relieve oxidative stress in skin tissue of ag-ing mice and inhibit the splenomegalia induced by aging.关键词
自然衰老小鼠/海洋鱼皮低聚肽/皮肤/氧化应激/脏器指数Key words
natural aging mice/marine fish skin oligopeptides/skin/oxidative stress/viscera index引用本文复制引用
朱嘉仪,鹿伟,刘心恬,泮雯霏,徐彩菊,杨敏..海洋鱼皮低聚肽对自然衰老小鼠皮肤改善的作用研究[J].中国食物与营养,2025,31(11):57-63,7.基金项目
浙江省基础公益研究计划项目(项目编号:LGF18H260009) （项目编号:LGF18H260009）
中国食品发酵工业研究院有限公司&北京市蛋白功能肽工程技术研究中心开放课题(项目编号:519600-I41802). （项目编号:519600-I41802）
