食品与发酵工业2025，Vol.51Issue(24)：18-26,9.DOI:10.13995/j.cnki.11-1802/ts.042825
水苏糖和谷氨酰胺复配的微生态制剂缓解肠易激综合征的临床研究
Clinical study on efficacy of a microecological preparation combining stachyose and glutamine in alleviating irritable bowel syndrome
摘要
Abstract
Irritable bowel syndrome(IBS)is a chronic intestinal disorder characterized by abdominal pain,bloating,and abnormal bowel movements,and its occurrence is associated with gut microbiota dysbiosis.Studies have shown that stachyose can regulate the gut microbiota and promote the growth of beneficial bacteria,while glutamine helps to repair the intestinal mucosal barrier.Based on this,the present study aims to evaluate the efficacy of a synbiotic formulation combining stachyose and glutamine in improving IBS symptoms and modulating gut microbiota through a randomized,double-blind,placebo-controlled trial.A total of 60 IBS patients were recruited from the Affiliated Hospital of Jiangnan University in Wuxi for a four-week intervention with the synbiotic formulation.A commercially available pro-biotic product with known therapeutic effects on IBS was used as a positive control.Fecal samples were collected post-intervention for met-agenomic sequencing to analyze differences in gut microbiota.Additionally,IBS severity and quality of life scales were assessed weekly.The results showed that after four weeks of intervention,disease severity in the synbiotic group was significantly improved,with a milder therapeutic effect compared to the probiotic control.Furthermore,the overall structure of the gut microbiota in patients exhibited significant changes.At the species level,the synbiotic formulation alleviated IBS symptoms by increasing the abundance of Bacteroides uniformis,Bacteroides ovatus,Faecalibacterium species,Bacteroides nordii,Akkermansia species,and Ruminococcus species.These findings provide a theoretical basis for the future application of prebiotic-based synbiotic formulations in relieving irritable bowel syndrome.关键词
肠易激综合征/肠道菌群/微生态制剂/水苏糖/谷氨酰胺Key words
irritable bowel syndrome/gut microbiota/microecological preparation/stachyose/glutamine引用本文复制引用
窦文轩,张程程,于雷雷,田丰伟,薛育政,翟齐啸..水苏糖和谷氨酰胺复配的微生态制剂缓解肠易激综合征的临床研究[J].食品与发酵工业,2025,51(24):18-26,9.基金项目
国家自然科学基金杰出青年科学基金项目(32425044) （32425044）
