食品科学技术学报2025，Vol.43Issue(6)：28-41,14.DOI:10.12301/spxb202500352
食品定向增效递送体系对结肠炎改善效应的调控作用与干预机制研究进展
Research Progress on Regulatory Effects and Intervention Mechanisms of Food Targeted Delivery Systems in Synergistic Amelioration of Colitis
摘要
Abstract
Ulcerative colitis is a severe chronic inflammatory bowel disease characterized by intestinal barrier dysfunction,immune dysregulation,and microbial dysbiosis.Although plant-derived bioactive compounds exhibit anti-inflammatory,antioxidant,and barrier-repairing potential,their oral bioavailability and targeted efficacy remain limited,necessitating advanced delivery strategies to enhance therapeutic outcomes.The spatiotemporal advantages of targeted and synergistic delivery systems in modulating the release kinetics,biological transport pathways,and mechanistic actions of bioactive compounds within the gastrointestinal tract were highlighted.By integrating pH-responsive,enzyme-triggered,and microbiota-activated materials with technologies such as sustained/controlled release,hierarchical structuring,mucosal permeation enhancement,and ligand-modified targeting,site-specific release,local enrichment,and synergistic effects of bioactive compounds were achieved by these systems.The localized concentration and duration of bioactives in the small intestine or colon were significantly improved,amplifying their ability to regulate immune-inflammatory networks,restore mucosal barriers,and remodel the microbiota-metabolite axis.Furthermore,synergistic regulatory mechanisms at the systemic level,including portal vein-lymphatic absorption ratios,microbiota-dependent metabolic conversion ratios,and circadian rhythm-responsive signaling were explored.Targeted delivery systems are not merely delivery vehicles,but also represent a precision intervention platform that orchestrates the biological fate and multi-target effects of functional ingredients.These advancements provided a systematic theoretical foundation and technological framework for functional food-based interventions in chronic inflammatory diseases such as colitis.关键词
定向递送/结肠炎/黏膜渗透/协同增效/调控机制Key words
targeted delivery/colitis/mucosal permeation/synergistic enhancement/regulatory mechanism分类
轻工纺织引用本文复制引用
XIAO Jie,TIAN Wenni,GUAN Yingxian,SONG Zengliu,ZHANG Qianqian,CHU Wanyu,LIU Yile..食品定向增效递送体系对结肠炎改善效应的调控作用与干预机制研究进展[J].食品科学技术学报,2025,43(6):28-41,14.基金项目
广东省引进创新创业团队项目(2019ZTO8N291) （2019ZTO8N291）
广东省青年珠江学者岗位计划项目(2019) （2019）
广东省大学生创新创业训练计划项目(S202310564102).Guangdong Provincial Introduced Innovation and Entrepreneurship Team Project(2019ZTO8N291) （S202310564102）
Guangdong Provincial Young Pearl River Scholars Program Project(2019) （2019）
Guangdong Provincial College Students'Innovation and Entrepreneurship Training Program Pro-ject(S202310564102). （S202310564102）
