中国食物与营养2025，Vol.31Issue(12)：54-58,5.
膳食胆碱摄入与哮喘患儿肺功能及疾病控制的关系
Association of Dietary Choline Intake with Pulmonary Function and Disease Control in Children with Asthma
摘要
Abstract
[Objective]To investigate the relationship between dietary choline intake and pulmonary function and disease control in children with asthma.[Method]A total of 80 children with bronchial asthma admitted to the Department of Pediatrics of Tangshan Maternal and Child Health Hospital from August 2024 to April 2025 were selected as the research objects.The daily choline intake was quantified by 24-hour dietary recall method,and the daily choline intake was continuously monitored for 7 days.The average value was taken and divided into three groups by fixed threshold method:high intake group(>250 mg/d,n=27),medium intake group(150-250 mg/d,n=26),low intake group(<150 mg,n=27).All children were treated with standardized asthma treat-ment and respiratory rehabilitation training.The forced vital capacity(FVC),one-second rate[forced expiratory volume in the first second/FVC(FEV1/FVC)]and peak expiratory flow(PEF)were measured before and after treatment.The asthma control test scale(ACT)and asthma control questionnaire(ACQ)were used to evaluate and compare.[Result]After treatment,the ACT scores of the three groups were higher than those before treat-ment.The ACT score:high-dose group>middle-dose group>low-dose group(P<0.05).The ACQ scores of the three groups after treatment were lower than those before treatment.ACQ score:high dose group<middle dose group<low dose group.The FVC,FEV1/FVC and PEF of the three groups were higher than those before treatment.The comparison between the groups showed that the three indexes were all high-dose group>middle-dose group>low-dose group,and the difference between the two groups was statistically significant(P<0.05).Pearson correlation analysis showed that dietary choline intake in children with asthma was positively correlated with ACT scale score and lung function indexes FVC,FEV1/FVC and PEF,and negatively correlated with ACQ scale score(P<0.05).[Conclusion]Dietary choline intake is associated with pulmonary function and disease control in children with asthma.Higher dietary choline intake shows potential to improve pulmonary function and reduce disease severity,and its clinical implementation is recommended.关键词
膳食胆碱摄入/支气管哮喘/肺功能Key words
dietary choline intake/bronchial asthma/lung function引用本文复制引用
ZHAO Jingwei,LI Xiaojuan,LIU Ying,CUI Huixian,LIU He..膳食胆碱摄入与哮喘患儿肺功能及疾病控制的关系[J].中国食物与营养,2025,31(12):54-58,5.基金项目
河北省医学科学研究重点课题计划(项目编号:202014737). （项目编号:202014737）
