中国食物与营养2025，Vol.31Issue(12)：59-65,7.
补充多种微量元素对高脂饮食大鼠抗氧化、抗炎、免疫功能的影响
Effects of Multiple Trace Elements Supplementation on Antioxidant,Anti-Inflammatory and Immune Functions in Rats Fed High-Fat Diet
摘要
Abstract
[Objective]To investigate the effects of multiple trace elements supplementation on antioxidant,anti-inflammatory and immune functions of rats on a high-fat diet,and to provide an experimental basis for trace elements supplementation.[Method]Four-week-old male SPF-grade Wistar rats were randomly divided into a control group,trace element supplementation group,high-fat diet group and high-fat diet with elemental supplementation group.The trace element supplementation group and high-fat diet with elemental supplementa-tion group were gavaged with trace elements(containing boron,vanadium,chromium,manganese,iron,cobalt,copper,zinc,selenium,strontium and molybdenum)daily for 8 weeks,and serum samples were col-lected to measure lipid levels,body antioxidant levels,inflammatory factor levels and immune function.[Result]The high-fat diet group showed increased levels of body weight,triglycerides,total cholesterol,and malondialdehyde,increased activity of enzymes such as xanthine oxidase,and increased percentage of CD8+T lymphocytes.Also,the high-fat diet group had decreased catalase activity,decreased levels of interleukin-4 and interleukin-10,and decreased proportions of CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocytes.In contrast,supplementation with multiple trace elements reversed the above abnormalities,while increasing total antioxidant capacity and glutathione levels,improving the enzymatic activities of superoxide dismutase,glutathione reductase and glutathione peroxidase,and decreasing the level of interleukin-6.[Conclu-sion]Multiple trace elements supplementation improved antioxidant capacity,anti-inflammatory capacity and immune function in rats on a high-fat diet.关键词
高脂饮食/微量元素/抗氧化/抗炎/免疫功能Key words
high-fat diet/micronutrient/antioxidant/anti-inflammatory/immune function引用本文复制引用
TANG Yanjin,QI Shaojun,ZHANG Zhengduo,WU Hong,LIU Rui,QIN Chuan,ZHANG Jiacheng,GAO Xibao..补充多种微量元素对高脂饮食大鼠抗氧化、抗炎、免疫功能的影响[J].中国食物与营养,2025,31(12):59-65,7.基金项目
内皮辅酶因子的工业化生产和应用研究(项目编号:2019GSF107002). （项目编号:2019GSF107002）
