现代食品科技2025，Vol.41Issue(12)：1-12,12.DOI:10.13982/j.mfst.1673-9078.2025.12.1281
松茸提取物改善AD模型小鼠认知障碍与作用机制
Tricholoma matsutake Extract Improves Cognitive Impairment in A Mouse Model of Alzheimer's Disease
摘要
Abstract
The protective mechanism of Tricholoma matsutake extract(TM)on an Alzheimer's disease(AD)mouse model was investigated.The AD mouse model was established using brain injections of Aβ42 oligomers.The behavioral,neuroinflammatory,oxidative stress,and gut microbiota-related indicators were assessed.The results showed that 2 g/kg of TM notably improved behavior and cognitive impairment.Pathological markers of AD,including inflammatory factors TNF-α,IL-1β,and MDA,were elevated in the model mice.However,these changes were reversed by the upregulation of anti-inflammatory factor IL-10 and the antioxidant enzymes SOD and GSH.Compared with the model group,the expression levels of inflammatory factors TNF-α and IL-1β were markedly reduced by 53.98%and 53.41%.In contrast,SOD and GSH levels increased substantially by 88.46%and 40.24%,respectively.TM inhibited the activation of microglial cell marker IBA-1 and astrocyte marker GFAP,with expression levels markedly decreased by 61.39%and 55.82%.These results indicate that TM improves neural damage by reducing neuroinflammation and oxidative stress.The 16S rRNA sequencing results showed that TM effectively ameliorates dysbiosis in AD mice,characterized by a notable increase in the relative abundance of SCFA-producing taxa,including members of Lachnospiraceae,Lactobacillus,and Prevotellaceae,while substantially decreasing the abundance of inflammation-related Proteobacteria.The adjustment of the Firmicutes/Bacteroidetes(F/B)ratio further suggests that the dysbiosis of gut microbiota has been ameliorated.In summary,the study demonstrated that TM effectively ameliorates neuroinflammation,reduces oxidative stress,and restores gut microbiota dysbiosis in AD mice,ultimately leading to improved cognitive function.Thus,TM shows promise as a potential treatment for AD.关键词
松茸提取物/阿尔茨海默病/神经炎症/肠道菌群Key words
Alzheimer's disease/Tricholoma matsutake extract/neuroinflammation/gut microbiota引用本文复制引用
王洋,李金壁,刘夫锋..松茸提取物改善AD模型小鼠认知障碍与作用机制[J].现代食品科技,2025,41(12):1-12,12.基金项目
国家重点研发计划项目(2021YFC2102700) （2021YFC2102700）
