中国食品添加剂2026，Vol.37Issue(1)：33-39,7.DOI:10.19804/j.issn1006-2513.2026.1.005
迷迭香叶酚类成分分析及抗糖尿病活性研究
Analysis of phenolic compounds in leaves of Rosmarinus officinalis L.and their anti-diabetic activity
摘要
Abstract
In order to study phenolic components of Rosmarinus officinalis L.leaves,the 80%ethanol extract of rosemary leaves was subjected to separation and purification,and the structures of the isolated compounds were elucidated by nuclear magnetic resonance spectroscopy(NMR).The most abundant compound,compound 1 was then evaluated for its effects on type 2 diabetes in a rat model induced by high sugar and high-fat diet combined with chemical induction.The Results showed that A total of 7 pheonolic compounds were obtained from the ethanol extract.They were identified as carnosic acid(1),columbaridione(2),atuntzensin A(3),7-α-methoxyrosmanol(4),7-β-methoxyrosmanol(5),rosmaqunione B(6),and 5-hydroxy-7,4'-dimethoxy flavone(7).Compounds 2 and 3 were isolated from rosemary for the first time.Compared to the model group,compound 1 was shown to reduce fasting blood glucose and increase insulin sensitivity.It also notably reduced collagen fiber content and deposition in the myocardium and blood vessels,hereby improving aortic vascular remodeling and myocardial fibrosis.The protective effects of compound 1 against diabetes-induced myocardial and vascular injury were reported for the first time.关键词
迷迭香/酚类/分离鉴定/鼠尾草酸/抗糖尿病活性Key words
Rosmarinus officinalis L./phenolics/isolation and identification/carnosic acid/anti-diabetic activity分类
轻工纺织引用本文复制引用
鹿爱娟,向晓琴,曹静,沈程,曹伟..迷迭香叶酚类成分分析及抗糖尿病活性研究[J].中国食品添加剂,2026,37(1):33-39,7.基金项目
湖南省自然科学基金青年基金项目(2023JJ40342) （2023JJ40342）
