中国食品添加剂2026，Vol.37Issue(1)：79-84,6.DOI:10.19804/j.issn1006-2513.2026.1.010
火麻油的急性毒性和致突变性研究
Study on acute toxicity and mutagenicity of hemp seed oil
王江伟 1杨慧 1王绍龙 1张洁宏 1王彦武 1彭亮1
作者信息
- 1. 广西壮族自治区疾病预防控制中心,南宁 530028
- 折叠
摘要
Abstract
Acute oral toxicity and mutagenicity of hemp seed oil were investigated to provide experimental evidence for its safety assessment.A single dose acute oral toxicity test was conducted by using the maximum tolerated dose approach,and one dose group of hemp seed oil at 18 g/kg body weight(BW)was established in mice.The mutagenicity was comprehensively evaluated by reverse mutation test,mammalian erythrocyte micronucleus test,and the mouse spermatogonial chromosome aberration test.The results showed that after administration of 18 g/kg BW of hemp seed oil,mice showed no signs of poisoning or death.With or without the addition of rat liver miorosomes S9,the number of revertant colonies of five strains(TA97a,TA98,TA100,TA102,and TA1535)at five doses of 50,158,500,1581,and 5000 μg/plate of hemp seed oil was similar to that of spontaneous revertant colonies,with MR values were all less than 2.Furthermore,no statistically significant differences were found in peripheral blood erythrocyte micronuclei rate,the PCE/RBC ratio,or the sperm abnormality rate between the treated mice and the mice in negative control group.Therefore,under the conditions of the present study,hemp seed oil demonstrated no evidence of acute toxicity or mutagenicity in the tested mice.关键词
火麻油/急性毒性/致突变性Key words
hemp seed oil/acute toxicity/mutagenicity分类
轻工纺织引用本文复制引用
王江伟,杨慧,王绍龙,张洁宏,王彦武,彭亮..火麻油的急性毒性和致突变性研究[J].中国食品添加剂,2026,37(1):79-84,6.
