乳业科学与技术2026，Vol.49Issue(1)：48-54,7.DOI:10.7506/rykxyjs1671-5187-20251104-076
酶法制备乳源免疫调节肽研究进展
Recent Progress in Enzymatic Preparation of Immunomodulatory Peptides from Milk
摘要
Abstract
Immunomodulatory peptides from milk(IPM)are a class of polypeptides with various biological activities such as immunomodulatory,antibacterial,and antioxidant properties.Compared to microbial fermentation,enzymatic hydrolysis offers distinct advantages including high specificity for cleavage sites,defined product structures,and superior process controllability,making it the preferred strategy for producing high-potency,standardized IPMs.This review summarizes recent advances in the enzymatic preparation of IPMs,focusing on enzyme selection strategies and the structure-activity relationship of IPMs regarding charge,hydrophobicity,and peptide chain length.Furthermore,it discusses the bidirectional mechanisms of IPMs in modulating innate and adaptive immunity,and highlights core industrial challenges such as debittering,membrane fouling control,and low oral bioavailability.Future research should integrate artificial intelligence assisted virtual screening and nano-encapsulation technologies to overcome bottlenecks in the application of IPMs.关键词
免疫调节肽/酶法制备/构效关系/肠道免疫/功能性食品Key words
immunomodulatory peptides/enzymatic preparation/structure-activity relationship/intestinal immunity/functional foods分类
轻工纺织引用本文复制引用
洪青,雍靖怡,王国骄,杨扬,贾向飞..酶法制备乳源免疫调节肽研究进展[J].乳业科学与技术,2026,49(1):48-54,7.基金项目
上海市国资委企业创新发展与能级提升项目(2022013) （2022013）
