中国食物与营养2026，Vol.32Issue(1)：11-17,7.
基于网络药理学及分子对接技术的黄精多糖调节血糖功效作用机制研究
Mechanism of Polygonatum Sibiricum Polysaccharides Regulating Blood Glucose Based on Network Pharmacology and Molecular Docking
摘要
Abstract
[Objective]To elucidate the hypoglycemic effects and mechanisms of Polygonatum sibiricum polysaccharide(PSP),network pharmacology and molecular docking techniques were employed to investigate its potential key components and mechanisms of action in regulating blood glucose.[Method]The component information and action targets of PSP were retrieved from the databases of TCMSP,PubChem and Swis-sTargetPrediction.Disease-related targets were acquired from Genecard and Drugbank databases.Protein-protein interaction(PPI)information between PSP's action targets and diabetes-related targets was analyzed using the String database.The relationship between action targets and the network of active components-action targets was constructed using Cytoscape 3.7.2.Enrichment analysis was conducted based on the Kyoto Encyclopedia of Genes and Genomes(KEGG).[Result]PSP primarily consists of fucose,arabinose,rhamnose,galactose,glucose,mannose,xylose,ribose,fructose,galacturonic acid and glucuronic acid.There are 64 action targets for the monosaccharide components and 57 shared targets between PSP and diabetes.In the PPI network,galacturonic acid,mannose,galactose and rhamnose emerged as core components.The KEGG pathways were primarily enriched in neuroactive ligand-receptor interaction,serotonergic synapse and peroxisome proliferator-activated receptors(PPARs)signaling pathway.[Conclusion]galacturonic acid,mannose,and galactose in PSP could regulate glucose levels through HSP90AA1,ACLY,G6PD and other target proteins and thereby mediate neuroactive ligand-receptor interactions,serotonergic synaptic pathways and PPARα pathways.This study provides novel insights into the mechanisms of PSP's hypoglycemic effects using network pharmacology methods,offering a theoretical basis for the development of functional products related to Polygonatum sibiricum.关键词
黄精多糖/血糖/网络药理学/分子对接Key words
Polygonatum sibiricum polysaccharides/blood glucose/network pharmacology/molecular docking引用本文复制引用
侯粲,肖杰,王梦倩,贾健斌,安泰,王黎明,郭斐..基于网络药理学及分子对接技术的黄精多糖调节血糖功效作用机制研究[J].中国食物与营养,2026,32(1):11-17,7.基金项目
北京市科技计划项目(项目编号:Z231100004123002). （项目编号:Z231100004123002）
