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Synthesis of a garlic protein-derived ACE inhibitory peptide and exploration of its antihypertensive mechanisms using integrated network pharmacology,transcriptomics,and in vitro cellular experiments

Lu Xiang Zhichang Qiu Xuguang Qiao Bin Zhang Lingyu Li Haihua Chen Zhenjia Zheng Dongxiao Sun-Waterhouse

未来食品学报（英文）2026，Vol.6Issue(6)：1103-1116,14.

未来食品学报（英文）2026，Vol.6Issue(6)：1103-1116,14.DOI:10.1016/j.jfutfo.2025.01.007

Synthesis of a garlic protein-derived ACE inhibitory peptide and exploration of its antihypertensive mechanisms using integrated network pharmacology,transcriptomics,and in vitro cellular experiments

Lu Xiang ¹Zhichang Qiu ¹Xuguang Qiao ¹Bin Zhang ¹Lingyu Li ¹Haihua Chen ²Zhenjia Zheng ¹Dongxiao Sun-Waterhouse³

作者信息

1. Key Laboratory of Food Nutrition and Health in Universities of Shandong,College of Food Science and Engineering,Shandong Agricultural University,Tai'an 271018,China
2. College of Food Science and Engineering,Qingdao Agricultural University,Qingdao 266109,China
3. Key Laboratory of Food Nutrition and Health in Universities of Shandong,College of Food Science and Engineering,Shandong Agricultural University,Tai'an 271018,China||School of Chemical Sciences,The University of Auckland,Auckland 1142,New Zealand
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摘要

关键词

Angiotensin Ⅰ-converting enzyme inhibitory peptide/Synthesis/Antihypertensive mechanism/Network pharmacology/Transcriptomics/Endothelial dysfunction/Cellular experiment

Key words

Angiotensin Ⅰ-converting enzyme inhibitory peptide/Synthesis/Antihypertensive mechanism/Network pharmacology/Transcriptomics/Endothelial dysfunction/Cellular experiment

引用本文复制引用

Lu Xiang,Zhichang Qiu,Xuguang Qiao,Bin Zhang,Lingyu Li,Haihua Chen,Zhenjia Zheng,Dongxiao Sun-Waterhouse..Synthesis of a garlic protein-derived ACE inhibitory peptide and exploration of its antihypertensive mechanisms using integrated network pharmacology,transcriptomics,and in vitro cellular experiments[J].未来食品学报（英文）,2026,6(6):1103-1116,14.

基金项目

This work was supported by the Special Fund for Leading Talent in Mount Tai Industry of Shandong Province(TSCY20200121)and the National Natural Science Foundation of China(32302133). （TSCY20200121）

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