食品与发酵工业2026，Vol.52Issue(6)：182-191,10.DOI:10.13995/j.cnki.11-1802/ts.043779
靶向代谢组学分析阿勒泰羊臀脂与分提产物对小鼠盲肠短链脂肪酸的影响
Targeted metabolomics reveals effects of Altay sheep tail fat fractions on cecal short-chain fatty acids in mice
摘要
Abstract
To scientifically evaluate the dietary health implications of Altay sheep caudal fat and its fractionated products,this study employed solvent fractionation technology to obtain high-melting-point hard stearin(SSO)and low-melting-point liquid olein(LSO)from Altay sheep caudal fat(SO).A systematic assessment was conducted to compare the effects of SO and its fractionated products on murine health.Results demonstrated that fractionation significantly altered the physicochemical properties of the lipids SSO was enriched with satu-rated fatty acids and exhibited a higher melting point,whereas LSO primarily contained unsaturated fatty acids with a lower melting point.Animal experiment results show that SSO intake significantly increases the obesity index and fat coefficient of mice,raises the content of isobutyric acid and isovaleric acid,and activates endocrine and metabolic disease pathways,suggesting that it may increase the risk of o-besity and inflammation.In contrast,LSO showed no significant adverse effects on murine growth parameters,major organ coefficients,or short-chain fatty acid profiles.Notably,LSO exhibited the lowest acid and peroxide values,indicating superior oxidative stability.Further-more,LSO consumption reduced isobutyric and isovaleric acid levels and downregulated pathways associated with glycolysis/gluconeogene-sis,nervous system function,endocrine and metabolic diseases,suggesting benefits for metabolic homeostasis.In conclusion,the health benefits of fractionated LSO surpass those of SO and SSO.This study provides a scientific foundation for the rational development and diet-ary application of animal-derived lipids.关键词
阿勒泰羊臀脂及其分提产物/生长指标/脏器系数/靶向代谢组学/短链脂肪酸Key words
Altay sheep caudal fat and its fractionated products/growth parameters/organ coefficients/targeted metabolomics/short-chain fatty acids引用本文复制引用
于俊飞,周建中,张可洋,王艺诺,锁晓红,刘宗洋,徐泽权,马欣..靶向代谢组学分析阿勒泰羊臀脂与分提产物对小鼠盲肠短链脂肪酸的影响[J].食品与发酵工业,2026,52(6):182-191,10.基金项目
新疆维吾尔自治区自然科学基金项目(2022D01B102) （2022D01B102）
