现代食品科技2026，Vol.42Issue(2)：40-49,10.DOI:10.13982/j.mfst.1673-9078.2026.2.1828
富含麦角甾醇的香菇柄提取物调节大鼠脂质代谢
Regulation of Lipid Metabolism in Rats using Ergosterol-rich Lentinus edodes Stalk Extracts
摘要
Abstract
The effects of ergosterol-rich Lentinus edodes stalk extracts on lipid metabolism remain unknown;thus,the content of ergosterol in the cap and stalk of L.edodes was analyzed using high performance liquid chromatography and the regulatory effects of the n-hexane extract(SEHE)and methanol/dichloromethane extract(SEMD)of the stalk on serum lipids,liver lipids and fecal lipids investigated in a rat model induced by a high-cholesterol diet.The ergosterol content of 7.82 mg·g-1 in the L.edodes cap was found to be significantly higher than the 5.24 mg·g-1 in the stalk,and the ergosterol content of SEHE was 20.31％(m/m)was higher than the 6.12％(m/m)obtained for SEMD.Animal experiments showed that both SEHE and SEMD could significantly reduce the level of low-density lipoprotein cholesterol(LDL-C),with reductions of 51.02％(P＜0.05)and 58.34％(P＜0.05),respectively,and effectively reduce the LDL-C/high-density lipoprotein cholesterol(HDL-C)ratio,with reductions of 54.61％(P＜0.05)and 53.04％(P＜0.05),respectively,in the rat serum.The two extracts were also found to reduce the cholesterol content(-19.31％,P＜0.05;-23.73％,P＜0.05)and triglyceride content(-9.82％,P=0.11;-24.83％,P＜0.05)in rat liver.SEMD was also found to significantly reduce the total cholesterol(TC)level in rat serum(-13.31％,P＜0.05).These findings indicate that both stalk extracts effectively regulated lipid metabolism in rats and have the potential to be used as functional food ingredients for the prevention of cardiovascular disease.关键词
香菇菌柄提取物/脂质代谢/血脂/麦角甾醇/食用菌Key words
Lentinus edodes stalk extract/lipid metabolism/blood lipid/ergosterol/edible fungus引用本文复制引用
隋嘉伟,崔丹丹,王惺雅,艾孜买提江·艾则孜,朱淑云,朱建华,高晓余,何文森..富含麦角甾醇的香菇柄提取物调节大鼠脂质代谢[J].现代食品科技,2026,42(2):40-49,10.基金项目
广东省粤北食药资源利用与保护重点实验室开放基金资助项目(FMR2023011Z) （FMR2023011Z）
食品营养与安全湖北省重点实验室开放基金(FNS-HBKL2023A01) （FNS-HBKL2023A01）
云南省精准营养与个性化食品制造重点实验室开放课题(YNJZKF2024A04) （YNJZKF2024A04）
"云南省省市一体化专项(202302AN360002) （202302AN360002）
江苏大学2024年大学生创新训练计划项目(202410299231Y) （202410299231Y）
