食品工业科技2026，Vol.47Issue(10)：56-62,7.DOI:10.13386/j.issn1002-0306.2025040017
金丝桃苷-大豆疏水肽基纳米复合物制备及其稳定性
Fabrication and Stabilization of Hyperoside-Soybean Hydrophobic Peptide Nanocomplex
摘要
Abstract
Hyperoside(HYP),a flavonoid with potent antioxidant,antitumor,and anti-inflammatory activities,has limited applications in pharmaceutical development and functional foods because of its poor water solubility and low bioavailability.In this study,hyperoside-loaded soybean hydrophobic peptide-based nanocomplexes(SPN-HYP)were prepared using a pH-driven method.The optimal HYP loading concentration was determined,and the physicochemical properties and bioaccessibility of the resulting nanocomplexes were systematically characterized.The results showed that soybean peptide hydrophobic aggregates could be used to construct HYP-loaded nanocomplexes,thereby improving the water solubility and stability of HYP.The nanoparticle dispersion was yellow in appearance,with an encapsulation efficiency above 90%,a loading capacity of 18.88%±0.033%,and a particle size ranging from 160 to 180 nm.Scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FTIR),and Zeta potential analysis confirmed the successful incorporation of HYP into SPN.After storage at 4℃for 15 days,the particle size variation remained below 10%.In vitro simulated gastrointestinal digestion showed that the bioaccessibility of HYP in the SPN-HYP system was significantly higher than that of free HYP(P<0.05).In addition,the SPN-HYP system effectively preserved the antioxidant activity of HYP and improved its stability and bioaccessibility during gastrointestinal digestion.Therefore,the soybean hydrophobic peptide-based nano-delivery system shows promising potential for enhancing the application of hyperoside in functional foods and pharmaceutical development.关键词
金丝桃苷/大豆多肽疏水聚集体/纳米复合物/稳定性/生物可及性Key words
hyperoside/soybean peptide hydrophobic aggregates/nanocomplexes/stability/bioaccessibility分类
轻工纺织引用本文复制引用
许晓韵,史阳凯,张远红,于立梅..金丝桃苷-大豆疏水肽基纳米复合物制备及其稳定性[J].食品工业科技,2026,47(10):56-62,7.基金项目
广东省本科教学质量与教学改革工程项目(粤教高函[2024]9号) （粤教高函[2024]9号）
广东省博士工作站粤人社函[2024]60号 （）
广东省研究生示范课程建设项目(2022SFKC071). （2022SFKC071）
