中国茶叶加工Issue(1)：41-46,6.DOI:10.15905/j.zgcyjg.2095-0306.2026.01.06
茶碱的药理学机制与临床应用研究进展
Research Progress on the Pharmacological Mechanism and Clinical Application of Theophylline
摘要
Abstract
Theophylline,a well-established therapeutic agent,has a long history of clinical application and is primarily used for the treatment of bronchial asthma and chronic obstructive pulmonary disease(COPD).In recent years,the potential mechanisms of action have been increasingly reported,including phosphodiesterase(PDE)inhibition,adenosine receptor antagonism,up-regulation of Interleukin-10(IL-10)secretion,down-regulation of Interleukin-8(IL-8)secretion,and enhancement of cellular processes such as surviva and,transcription,as well as histone deacetylase activation,and enhancement of protein phosphatase 2A activity.Moreover theophylline has potential therapeutic value in the nervous system,urinary system,cardiovascular system,and anti-tumor.Therefore,this paper systematically reviews the mechanisms of action and pharmacological applications of theophylline,aiming to provide a theoretical basis for the in-depth development and clinical utilization.关键词
茶碱/作用机制/药代动力学/药理学应用Key words
Theophylline/Mechanism of action/Pharmacokinetics/Pharmacological applications分类
医药卫生引用本文复制引用
李亚男,余莉惠,罗会清,赵世宽,杨瑞娟..茶碱的药理学机制与临床应用研究进展[J].中国茶叶加工,2026,(1):41-46,6.基金项目
云南省国际科技特派员项目(202403AK140038) （202403AK140038）
