中国果菜2026，Vol.46Issue(4)：7-12,6.DOI:10.19590/j.cnki.1008-1038.2026.04.002
新型芳酰胺化合物的合成及抑菌活性研究
Design,Synthesis and Fungicidal Activity of Novel Arylamide Compounds
摘要
Abstract
To develop novel fungicides suitable for the green control of fruit and vegetable diseases,12 nitro-containing aromatic amide compounds were designed and synthesized in this study.Their structures were confirmed by nuclear magnetic resonance(NMR),and their fungicidal activities against 4 common pathogenic fungi were evaluated.The results showed that most compounds exhibited moderate activity against Alternaria solani and Sclerotinia sclerotiorum,and weak activity against Botrytis cinerea and Rhizoctonia solani.Structure-activity relationship(SAR)analysis indicated that introduction of a 6-methyl group at the R2 position had a weak effect on antifungal activity,whereas addition of a nitro group at the R3 position generally led to decreased activity.Compounds I-2,I-8 and I-9 displayed favorable broad-spectrum activity,with inhibitory rates exceeding 50％ against four pathogens.Among them,compound I-9 showed the best activity,with inhibition rates of 75.75％ against S.sclerotiorum,which could be used as a lead compound for further optimization,providing solutions for the control of major diseases in fruits and vegetables and contributing to the green and sustainable development of the fruit and vegetable industry.关键词
芳香酰胺/抑菌活性/分子设计/构效关系Key words
Aromatic amide/fungicidal activity/molecular design/structure-activity relationship分类
化学化工引用本文复制引用
郝泽生,李启鹏,王佳颖,陈吉祥,王海利,张晓慷,张新刚,江忠萍,韩金涛..新型芳酰胺化合物的合成及抑菌活性研究[J].中国果菜,2026,46(4):7-12,6.基金项目
山东省重点研发计划(2024CXGC010908) （2024CXGC010908）
山东省自然科学基金(ZR2022QC224) （ZR2022QC224）
山东省农业科学院农业科技创新工程(CXGC2024F18、CXGC2025C17、CXGC2026H27) （CXGC2024F18、CXGC2025C17、CXGC2026H27）
