乳业科学与技术2026，Vol.49Issue(2)：44-50,7.DOI:10.7506/rykxyjs1671-5187-20251218-089
基于肠道微生态调控的益生菌与益生元协同辅助治疗便秘:机制、证据与展望
Synergistic Adjuvant Therapy of Constipation with Probiotics and Prebiotics via Modulation of Gut Microbiota:Mechanisms,Evidence,and Prospects
摘要
Abstract
Constipation is a prevalent functional gastrointestinal disorder.Conventional laxative therapies for constipation often entail risks of dependence and adverse effects.With the growing recognition of the crucial role of gut microbiota dysbiosis in its pathogenesis,gut microbiota modulation has emerged as a core strategy in novel therapies.Synbiotics,a combination of probiotics and prebiotics,demonstrates significant therapeutic potential through synergistic mechanisms:prebiotics selectively promote the colonization and proliferation of probiotics,and they synergistically optimize gut microbiota composition,enhance the production of short-chain fatty acids,and subsequently improve intestinal barrier function,regulate immune responses,and stimulate intestinal motility.Clinical evidence indicates that specific synbiotic formulations outperform single-component interventions in improving stool frequency,consistency,and overall symptoms.This advantage stems from the"nutrition-microbiota-metabolism"multiple-pathway synergistic effect.Future research should prioritize the development of personalized synbiotic regimens based on gut microbiota functional prediction,conduct large-scale clinical trials for functional validation,and explore their integration with novel delivery systems and functional food carriers,thereby advancing the development of constipation treatment toward the integration of precision microbiota-based intervention and enhancing its clinical utility and patients'quality of life.关键词
益生菌/益生元/便秘/肠道微生态/短链脂肪酸/协同作用Key words
probiotics/prebiotics/constipation/gut microbiota/short-chain fatty acids/synergistic effect分类
轻工纺织引用本文复制引用
袁雪峰,许倩,周鸿淼,李旭,逄晓阳,吕加平,张书文..基于肠道微生态调控的益生菌与益生元协同辅助治疗便秘:机制、证据与展望[J].乳业科学与技术,2026,49(2):44-50,7.基金项目
新疆两区科技发展计划项目(2023LQ02003) （2023LQ02003）
新疆生产建设兵团自然科学支持计划项目(2024DB013 （）
2024AB050) （）
国家自然科学基金地区科学基金项目(32560567) （32560567）
