中国食物与营养2026，Vol.32Issue(4)：180-185,6.
膳食饱和脂肪酸与不饱和脂肪酸与女性子宫内膜癌发病风险的关联
Association Between Dietary Saturated and Unsaturated Fatty Acids and The Risk of Endometrial Cancer in Women
摘要
Abstract
[Objective]To explore the relationship between dietary saturated and unsaturated fatty acids and the risk of endometrial cancer in women.[Method]A case-control study was used,382 newly diagnosed endometrial cancer patients treated from January 2020 to January 2025 were selected as the observation group,while 382 healthy volunteers were selected as the control group.The differences in dietary fatty acid intake and clinical baseline data between the two groups were compared to analyze the influencing factors of endometrial cancer occurrence.[Result]The proportion of monounsaturated fatty acid(MUFA)intake in the observation group was(38.89±8.22)％,which was lower than that in the control group(48.10±9.03)％(P<0.05),while the proportion of polyunsaturated fatty acid(PUFA)intake and n-6/n-3 ratio were(32.48±9.05)％and(7.06±1.33),respectively,which were higher than those in the control group(23.35±8.17)％and(5.69±1.12)(P<0.05).There was no statistically significant difference in the intake ratio of saturated fatty acids(SFA)between the observation group and the control group(P>0.05).The body mass index(BMI)≥24 kg/m2,smoking,diabetes,family history of endometrial cancer,and the proportion of non pregnancy in the observation group were 41.62％,31.68％,34.55％,29.58％,and 28.27％,respectively,which were higher than those in the control group 22.25％,19.11％,21.20％,5.76％,and 9.42％(P<0.05).Logistic regression analysis showed that MUFA intake ratio,PUFA intake ratio,n-6/n-3 ratio,body mass index,family history of endometrial cancer,and parity were the influencing factors for the occurrence of endometrial cancer(P<0.05),the area under the ROC curve for predicting the occurrence of endometrial cancer was 0.910(95％CI:0.862-0.958)(P<0.05),with sensitivity and specificity of 92.90％and 76.60％,respectively.[Conclusion]Dietary MUFA,PUFA,and n-6/n-3 ratio are influencing factors for the incidence of endometrial cancer in women.Scientific and reasonable intake of fatty acids can help reduce the risk of endometrial cancer.关键词
膳食/饱和脂肪酸/不饱和脂肪酸/子宫内膜癌/影响因素Key words
diet/saturated fatty acids(SFA)/unsaturated fatty acids(UFA)/endometrial cancer/influencing factor引用本文复制引用
费国辉,苏妍,郑韦..膳食饱和脂肪酸与不饱和脂肪酸与女性子宫内膜癌发病风险的关联[J].中国食物与营养,2026,32(4):180-185,6.基金项目
河北省医学科学研究重点课题计划项目(项目编号:20241000). （项目编号:20241000）
