现代食品科技2026，Vol.42Issue(4)：11-21,11.DOI:10.13982/j.mfst.1673-9078.2026.4.0065
基于血清非靶代谢组学分析鞣花酸改善过敏性鼻炎的作用机制
Mechanisms Underlying Ellagic Acid's Effects on Improving Allergic Rhinitis based on Serum Untargeted Metabolomics Analysis
摘要
Abstract
To investigate the therapeutic effects of ellagic acid(EA)on allergic rhinitis(AR)and its potential mechanisms of metabolic regulation,different doses of EA(4,8,and 16 mg.kg-1)were administered to ovalbumen-induced AR rats.Pathological changes in nasal mucosa and lung tissue were observed,levels of IgE,histamine,IL-4,and IL-6 in serum were measured,and metabolite changes along with their correlations with allergic inflammation markers were analyzed using untargeted metabolomics.The results showed that EA interventions reduced the number of mast cells in the nasal mucosa and lung tissue and decreased the levels of IgE,histamine,IL-4,and IL-6 in the serum,with the high-dose group showing the most significant improvements(reductions of 26.40％,23.79％,21.65％,and 35.00％in the abovementioned indicators,respectively).Untargeted metabolomics identified 43 differential metabolites,among which 22 were significantly restored after intervention(P＜0.05),including 19 metabolites positively correlated and 3 negatively correlated with allergic inflammation markers.Enrichment analysis revealed that the restored metabolites were significantly enriched in three pathways:arachidonic acid metabolism,primary bile acid biosynthesis,and porphyrin metabolism.In conclusion,EA alleviates AR by improving pathological tissue conditions,reducing allergic inflammation markers,and regulating key metabolic pathways.These findings provide new insights into the application of EA and related polyphenols in the development of anti-allergic functional foods.关键词
鞣花酸/功能活性成分/过敏性鼻炎/血清非靶代谢组学/花生四烯酸代谢Key words
ellagic acid/bioactive components/allergic rhinitis/serum untargeted metabolomics/arachidonic acid metabolism引用本文复制引用
张朴康,翟舒心,张妮,滕建文,黄丽,夏宁..基于血清非靶代谢组学分析鞣花酸改善过敏性鼻炎的作用机制[J].现代食品科技,2026,42(4):11-21,11.基金项目
国家自然科学基金项目项目(32160571) （32160571）
